RECRUITINGPhase 3INTERVENTIONAL
A Master Protocol for Orforglipron (LY3502970) in Participants With Obesity or Overweight With and Without Type 2 Diabetes
A Master Protocol to Investigate the Efficacy and Safety of Orforglipron Tablet Once Daily Compared With Placebo in Participants With Obesity or Overweight With and Without Type 2 Diabetes
About This Trial
The purpose of this Master Protocol is to support two studies to see how well and how safely orforglipron works compared to placebo in participants who have obesity or overweight with or without type 2 diabetes. Participants will be screened for about 4 weeks, after which they will enroll into either J2A-MC-GZP1, NCT06972459 (do not have type 2 diabetes) or J2A-MC-GZP2, NCT06972472 (have type 2 diabetes).
Who May Be Eligible (Plain English)
There are no specific eligibility criteria for the Master Protocol.
- See study GZP1 for eligibility criteria relevant to participants with obesity and overweight without type 2 diabetes
- See study GZP2 for eligibility criteria relevant to participants with type 2 diabetes
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
There are no specific eligibility criteria for the Master Protocol.
* See study GZP1 for eligibility criteria relevant to participants with obesity and overweight without type 2 diabetes
* See study GZP2 for eligibility criteria relevant to participants with type 2 diabetes
Treatments Being Tested
DRUG
Orforglipron
Administered orally
DRUG
Placebo
Administered orally
Locations (20)
Clinical Research Institute of Arizona (CRI) - Sun City West
Sun City West, Arizona, United States
Novak Clinical Research - Tucson - North La Cholla Boulevard
Tucson, Arizona, United States
Norcal Endocrinology & Internal Medicine
San Ramon, California, United States
Southern California Clinical Research
Santa Ana, California, United States
Care Access - Thousand Oaks
Thousand Oaks, California, United States
Accel Research Sites - DeLand Clinical Research Unit
DeLand, Florida, United States
Innovation Medical Research Center - Fort Lauderdale
Fort Lauderdale, Florida, United States
Indago Research & Health Center, Inc
Hialeah, Florida, United States
Encore Medical Research
Hollywood, Florida, United States
West Orange Endocrinology P.A.
Ocoee, Florida, United States
Care Access - Tampa
Tampa, Florida, United States
Conquest Research
Winter Park, Florida, United States
Accel Research Sites - NeuroStudies Clinical Research Unit
Decatur, Georgia, United States
Care Access - Decatur
Decatur, Georgia, United States
Javara - Privia Medical Group Georgia - Savannah
Savannah, Georgia, United States
North Georgia Clinical Research
Woodstock, Georgia, United States
Solaris Clinical Research
Meridian, Idaho, United States
Care Access - New Iberia
New Iberia, Louisiana, United States
Endocrine and Metabolic Consultants
Rockville, Maryland, United States
Javara - Privia Medical Group - Silver Spring
Silver Spring, Maryland, United States