FITting Non-invasive Tests in Lynch Syndrome Surveillance

Who May Qualify: - Have a diagnosis of LS with a confirmed pathogenic variant in MLH1, MSH2, MSH6, PMS2 or EPCAM genes. - Aged 20 - 75 years (for those with pathogenic variants in MLH1, MSH2, and EPCAM) - Aged 30 - 75 years (for those with pathogenic variants in PMS2 or MSH6). - Have an upcoming standard of care (SOC) colonoscopy appointment in line with standard LS surveillance guidelines (NCCN). - Willing to sign willing to sign a consent form, collect stools samples and complete surveys Who Should NOT Join This Trial: - Individuals who have not proceeded with genetic testing and therefore are not known to have LS, despite family history and/or criteria for testing. - Individuals who have previously undergone a subtotal or total colectomy. - Newly diagnosed Lynch Syndrome patients \< 20 years old with a pathogenic variant in MLH1, MSH2 or EPCAM, MSH6 or PMS2. - Newly diagnosed Lynch Syndrome patients \< 30 years old with a pathogenic variant in MSH6 or PMS2. - Individuals who are pregnant. - Individuals with inflammatory bowel disease or active malignancy. - Individuals not willing or able to sign willing to sign a consent form. Always talk to your doctor about whether this trial is right for you.