Study of Targeted Therapies for the Treatment of Adult Participants With Active Psoriatic Arthritis

Who May Qualify: - Participant is willing and able to comply with procedures required in the Master Protocol and substudies. - Participant has a documented clinical diagnosis of PsA with symptom onset at least 6 months prior to the Screening Visit and fulfillment of the Classification Criteria for Psoriatic Arthritis (CASPAR) at Screening Visit. - Participant has active disease defined as greater than or equal to 3 tender joints (based on 68 joint count) and greater than or equal to 3 swollen joints (based on 66 joint count) at both the Screening Visit and Baseline. - Participant has active plaque PsO and/or a documented history of plaque PsO. - Participant must demonstrate intolerance or inadequate response to 1 to 2 targeted therapies (biologic or targeted synthetic disease-modifying antirheumatic drugs) approved for the treatment of PsA Who Should NOT Join This Trial: - Participants who have had major surgery performed within 12 weeks prior to randomization or plan to have a major surgery during conduct of the study (e.g., aneurysm removal, stomach ligation). - Participants with the following chronic or active infections: Are infected with human weakened immune system virus (HIV), active hepatitis B virus (HBV) or hepatitis C virus(HCV) infection, active tuberculosis(TB) - Active skin disease other than psoriasis (PsO) which could interfere with the assessment of PsO. - History of fibromyalgia, any arthritis with onset prior to age 17 years, or current diagnosis of inflammatory joint disease other than psoriatic arthritis (PsA) (including but not limited to rheumatoid arthritis, gout, overlap connective tissue diseases, scleroderma, polymyositis, dermatomyositis, systemic lupus erythematosus). Always talk to your doctor about whether this trial is right for you.