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RECRUITINGOBSERVATIONAL

Observational Study of Oral Atogepant to Evaluate Real-World Effectiveness in Adult Participants With Migraine

A ProspeCtive ObseRvatioNal Study of Atogepant Effectiveness in Routine Clinical Practice

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Migraine is a neurological disease characterized by moderate or severe headache, associated with nausea, vomiting, and/or sensitivity to light and sound. This study will evaluate the effectiveness of atogepant in treating adult participants with migraine in a real-world setting. Atogepant is an approved drug for preventive treatment of migraine in adults. Approximately 1000 adult participants who are prescribed atogepant by their doctors will be enrolled in this study across the world. Participants will receive atogepant oral tablets as prescribed per standard clinical practice and will be followed for 2 years. There is expected to be no additional burden for participants in this trial. Participants will attend regular visits during the study at a hospital or clinic according to their routine clinical practice.

Who May Be Eligible (Plain English)

Who May Qualify: - At least 1-year history of migraine with or without aura consistent with a diagnosis according to the International Classification of Headache Disorders (ICHD)-3, 2018. - Prescribed atogepant according to the relevant approved local label. - For participants who initiate atogepant at the prescribing physician or treating health care provider (HCP) discretion as part of their routine clinical care, the decision to administer atogepant must be made prior to and independent of recruitment into the study. - Willing and able to comply with the requirements of the study. - Not on concomitant preventive medication for migraine or have been on a stable preventive medication for migraine for at least 3 months prior to enrollment in the study. If on a stable preventive medication, the prescribing physician or treating HCP and participant must confirm that there is no plan to change concomitant preventive medication during the first 12 weeks of the study. Who Should NOT Join This Trial: - Previously exposed to atogepant as routine therapy or from clinical trials experience prior to entry. - Contraindications to atogepant as per local labeling. - Pregnant or planning to be pregnant or women of childbearing potential not using contraception. - Enrolled in any interventional studies that may include investigational compounds for migraine, or non-AbbVie observational studies. - In the opinion of the prescribing physician or treating HCP, the participant has a history or current evidence of any condition that might interfere with patient's ability to comply with the study requirements. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * At least 1-year history of migraine with or without aura consistent with a diagnosis according to the International Classification of Headache Disorders (ICHD)-3, 2018. * Prescribed atogepant according to the relevant approved local label. * For participants who initiate atogepant at the prescribing physician or treating health care provider (HCP) discretion as part of their routine clinical care, the decision to administer atogepant must be made prior to and independent of recruitment into the study. * Willing and able to comply with the requirements of the study. * Not on concomitant preventive medication for migraine or have been on a stable preventive medication for migraine for at least 3 months prior to enrollment in the study. If on a stable preventive medication, the prescribing physician or treating HCP and participant must confirm that there is no plan to change concomitant preventive medication during the first 12 weeks of the study. Exclusion Criteria: * Previously exposed to atogepant as routine therapy or from clinical trials experience prior to entry. * Contraindications to atogepant as per local labeling. * Pregnant or planning to be pregnant or women of childbearing potential not using contraception. * Enrolled in any interventional studies that may include investigational compounds for migraine, or non-AbbVie observational studies. * In the opinion of the prescribing physician or treating HCP, the participant has a history or current evidence of any condition that might interfere with patient's ability to comply with the study requirements.

Locations (20)

Neurology and Neurodiagnostics of Alabama /ID# 267614
Hoover, Alabama, United States
Rehabilitation & Neurological Services /ID# 267612
Huntsville, Alabama, United States
Barrow Neurological Institute - Dignity Health St. Joseph's Hosp and Medical Ctr /ID# 267610
Phoenix, Arizona, United States
Kenneth Martinez MD, A Medical Corp /ID# 267834
Aliso Viejo, California, United States
Los Angeles Headache Center /ID# 267570
Los Angeles, California, United States
Alcanza Clinical Research, LLC /ID# 267838
Lake Mary, Florida, United States
Norton Cancer Institute - St. Matthews /ID# 267605
Louisville, Kentucky, United States
Dent Neurologic Institute - Amherst /ID# 267606
Amherst, New York, United States
Northwell Health - Great Neck /ID# 280705
Great Neck, New York, United States
Northwell Health /ID# 267596
New York, New York, United States
Thomas Jefferson University Hospital /ID# 267572
Philadelphia, Pennsylvania, United States
Inova Health Care System /ID# 267615
Falls Church, Virginia, United States
Neuroscience Group /ID# 267571
Neenah, Wisconsin, United States
Cliniques Universitaires UCL Saint-Luc /ID# 270545
Brussels, Brussels Capital, Belgium
Universitair Ziekenhuis Brussel /ID# 269799
Jette, Brussels Capital, Belgium
Chu Tivoli /ID# 271254
La Louvière, Hainaut, Belgium
Centre Hospitalier Régional de la Citadelle /ID# 270539
Liège, Liege, Belgium
Groupe Sante CHC - Clinique du MontLegia /ID# 270218
Liège, Liege, Belgium
OLV Ziekenhuis Aalst /ID# 270284
Aalst, Oost-Vlaanderen, Belgium
AZ Sint-Jan Brugge /ID# 270540
Bruges, West-Vlaanderen, Belgium