Efficacy, Tolerability, and Cognitive Effects of Deep Transcranial Magnetic Stimulation for Bipolar Depression

Who May Qualify: Confirmed diagnosis of bipolar depression; - age between 18 and 65 years; - a 17-item Hamilton Depression Rating Scale (HDRS-17) score \>= 17, - a stable pharmacological regimen maintained for at least 4 weeks prior to the beginning of the treatment phase ; - for participants who had previously received antidepressant therapy, a minimum 4-week waiting period after previous treatment followed by re-evaluation. Who Should NOT Join This Trial: - a lifetime history of other psychiatric disorders, neurological diseases, or severe brain injury; - receipt of electroconvulsive therapy, rTMS, transcranial direct current stimulation, transcranial alternating current stimulation, or other neurostimulation treatments within the previous 3 months; - contraindications to magnetic stimulation, including epilepsy, cardiovascular disorders, or metallic implants in the head; - the presence of hypomanic/manic symptoms at baseline or a score greater than 12 on the Young Mania Rating Scale (YMRS); - pregnancy or lactation. Always talk to your doctor about whether this trial is right for you.