RECRUITINGOBSERVATIONAL

Hypertension Explored in Long-term Postpartum Follow-up in Later Life

Hypertension Explored in Long-term Postpartum Follow-up in Later Life (HELPFUL)

About This Trial

The purpose of this study is to understand more about why women who have had hypertensive pregnancies may be at increased risk of high blood pressure and why these women are often at increased risk of heart and blood vessel disease later in life.

Who May Be Eligible (Plain English)

Who May Qualify: - Inclusion Criteria - Participant is willing and able to give willing to sign a consent form for participation in the study - Female who had a pregnancy 10 to 25 years prior - Able (in the investigator's opinion) and willing to comply with all study requirements. - Adequate understanding of verbal and written English Who Should NOT Join This Trial: - The participant may not enter the study if ANY of the following apply: - Over 10 weeks pregnant during the course of the study - Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status - Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study For exclusion of MRI component only: • Unsuitable for MRI based on the responses to the MRI screening form. The participant may still be included in other parts of the study. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Inclusion Criteria * Participant is willing and able to give informed consent for participation in the study * Female who had a pregnancy 10 to 25 years prior * Able (in the investigator's opinion) and willing to comply with all study requirements. * Adequate understanding of verbal and written English Exclusion Criteria: * The participant may not enter the study if ANY of the following apply: * Over 10 weeks pregnant during the course of the study * Evidence of congenital heart disease or significant chronic disease relevant to cardiovascular or metabolic status * Any significant disease or disorder which, in the opinion of the investigator, might influence the participant's ability to participate in the study For exclusion of MRI component only: • Unsuitable for MRI based on the responses to the MRI screening form. The participant may still be included in other parts of the study.

Treatments Being Tested

OTHER

Hypertensive pregnancy

Participants will attend one visit lasting approximately 3-4 hours on a single day or split over multiple visits to complete all measures. Participants will first be asked to provide written informed consent for the study. Participants' anthropometric measures (waist-to-hip ratio, height and weight, hip and waist circumference and left arm circumference and resting blood pressures will then be taken. After this, the participants will undergo cardiopulmonary exercise testing, followed by magnetic resonance imaging, echocardiography, retinal imaging and vascular imaging of the ear. The study visit will conclude with participants being provided with a wrist-worn physical activity monitor to wear for 7-9 days following the visit. These monitors will provide objective measures of physical activity while people go about their normal activities.

Locations (1)

University of Oxford Department of Cardiovascular Medicine

Oxford, United Kingdom