Tocilizumab for Acute Chest Syndrome

Who May Qualify: - Adults ≥ 12 years of age - Prior diagnosis of sickle cell disease (Hb SS, Hb SC, Hb Sb+, and Hb Sb0) Who Should NOT Join This Trial: - Pregnant patients or breastfeeding mothers. - Prior treatment with gene therapy or a stem cell transplant. - Current enrollment in a clinical trial involving an FDA-regulated drug or biologic. - Current neutropenia (absolute neutrophil count \< 1000/mm\^3) - Current thrombocytopenia (platelet count \< 50,000 mm\^3) - Aspartate aminotransferase (AST) or alanine transaminase (ALT) \> 10 times the upper limit of normal (ULN) - History of tuberculosis (TB). - Positive purified protein derivative (PPD) TB screening test. - On active therapy with a Bruton's tyrosine kinase-targeted agent, which include the following: Acalabrutinib, Ibrutinib, Zanubrutinib - On active therapy with a JAK2-targeted agent, which include the following: Baricitinib, Ruxolitinib, Tofacitinib, Upadacitinib - Any of the following biologic immunosuppressive agent (and any biosimilar versions thereof) administered in the past 6 months: Abatacept, Adalimumab, Alemtuzumab, Atezolizumab, Belimumab, Blinatumomab, Brentuximab, Certolizumab, Daratumumab, Durvalumab, Eculizumab, Elotuzumab, Etanercept, Gemtuzumab, Golimumab, Ibritumomab, Infliximab, Inotuzumab, Ipilimumab, Ixekizumab, Moxetumomab, Nivolumab, Obinutuzumab, Ocrelizumab, Ofatumumab, Pembrolizumab, Polatuzumab, Rituximab, Sarilumab, Secukinumab, Tocilizumab, Tositumumab, Tremelimumab, Urelumab, Ustekinumab Always talk to your doctor about whether this trial is right for you.