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RECRUITINGPhase 1 / Phase 2INTERVENTIONAL

Minocycline for Chronic Autoimmune Uveitis

The Efficacy and Safety of Minocycline for Chronic Autoimmune Uveitis

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Autoimmune uveitis is one kind of non-infectious, sight-threatening, relapsing and severe ocular disease. Approximately 20%-25% autoimmune uveitis patients suffer from the dilemma of blindness for the chronic and persistent inflammatory state in the eyes, which results in continuous destroy in the structure of the eyes and gradually leads to irreversible damage on visual function. However, it shows limiting efficacy of current treatment including glucocorticoids, immunosuppressant and biologics for chronic autoimmune uveitis. Minocycline has been regarded to have anti-apoptosis and immunemodulatory function for decades and it has been illustrated to be beneficial in several neuro-degenerative and neuro-inflammatory diseases. This trial aims to investigate the efficacy and safety of minocycline for chronic autoimmune uveitis with retinal degenerative changes.

Who May Be Eligible (Plain English)

Who May Qualify: - Participant diagnosed of autoimmune conditions (where your immune system attacks your own body)s with visual function damage (decrease of BCVA, loss of retinal structure) - Participant aged from 18-60 years old. - Participant that signed the willing to sign a consent form document and is able to complete the following visits. Who Should NOT Join This Trial: - Participant is allergy to minocycline or tetracyclines. - Participant has no contraindications of minocycline or tetracyclines. - Participant has an abnormal function of liver, heart, kidney and thyroid. - Participant is using glucocorticoids, immunosuppressants or biologics. - Female that is pregnant, breast-feeding or planning to become pregnant. - Participant that is currently using other medications for other diseases. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Participant diagnosed of autoimmune diseases with visual function damage (decrease of BCVA, loss of retinal structure) * Participant aged from 18-60 years old. * Participant that signed the informed consent document and is able to complete the following visits. Exclusion Criteria: * Participant is allergy to minocycline or tetracyclines. * Participant has no contraindications of minocycline or tetracyclines. * Participant has an abnormal function of liver, heart, kidney and thyroid. * Participant is using glucocorticoids, immunosuppressants or biologics. * Female that is pregnant, breast-feeding or planning to become pregnant. * Participant that is currently using other medications for other diseases.

Treatments Being Tested

DRUG

minocycline

minocycline capsule 100mg per day orally

Locations (1)

Zhongshan Ophthalmic Center
Guangzhou, Guangdong, China