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RECRUITINGINTERVENTIONAL

Effect of Chronotherapy on Blood Pressure - Time of Intake of Blood Pressure Lowering Drugs

Chronotherapy in Hypertension - a Study of Blood Pressure Levels Following Intake of Antihypertensive Medication in the Morning or at Bedtime

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

A randomized clinical trials with cross-over design to evaluate changes in blood pressure, renal function (creatinine, estimated glomerular filtration), LDL and HDL-cholesterol after taking antihypertensive drugs in the morning or at bedtime. Blood pressure will be estimated by ambulatory blood pressure measurements. There will be a shift in time of drug intake after 8 weeks for each participant. Approximately 100 individuals aged 40-75 years and on stable anti-hypertensive treatment and blood pressure \<150/95 mm Hg will be recruited. No new drugs will be introduced during the study.

Who May Be Eligible (Plain English)

Who May Qualify: - Diagnosis of hypertension - Stable antihypertensive treatment at least 8 weeks prior to inclusion - One to four antihypertensive drugs Who Should NOT Join This Trial: - Atrial fibrillation/flutter - Diabetes - Previous stroke or TIA - Heart failure - Ischemic heart disease - Peripheral artery disease - Malignant disease with less than one year expected survival - Inability to follow study protocol (for instance shift work) Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Diagnosis of hypertension * Stable antihypertensive treatment at least 8 weeks prior to inclusion * One to four antihypertensive drugs Exclusion Criteria: * Atrial fibrillation/flutter * Diabetes * Previous stroke or TIA * Heart failure * Ischemic heart disease * Peripheral artery disease * Malignant disease with less than one year expected survival * Inability to follow study protocol (for instance shift work)

Treatments Being Tested

OTHER

Time of ordinary antihypertensive medication intake

Time of ordinary antihypertensive medication intake

Locations (3)

Sahlgrenska University Hospital, Mölndal
Gothenburg, Sweden
Närhälsan Billingen Primary Health Care Centre
Skövde, Sweden
Närhälsan Norrmalm Primary Health Care Centre
Skövde, Sweden