Modeling Macrophages Activation Pattern in X-linked Adrenoleukodystrophy, Metachromatic Leukodystrophy and Adult Onset Leukoencephalopathy With Axonal Spheroids and Pigmented Glia

Who May Qualify: Boys aged between 3 and 18 years (inclusive) diagnosed with C-CALD (elevated levels of VLCFA and leukodystrophy at brain MRI) - Boys or girls aged between 15 months and 18 years (inclusive) diagnosed with MLD (low ARSA activity and accumulation of sulfatides in urine) - Presymptomatic boys carrying ABCD1 mutations aged between 3 and 18 years (inclusive) (PRE-ALD) - Adult males or females aged between 18 and 60 diagnosed with MLD (low ARSA activity and accumulation of sulfatides in urine) - Males aged between 18 and 60 years diagnosed with AMN (elevated VLCFA and clinical symptoms of AMN without leukodystrophy at brain MRI) - Males aged between 18 and 60 years diagnosed with CALD (elevated VLCFA with leukodystrophy at brain MRI) - Adult males or females aged between 18 and 60 years diagnosed with ALSP (CSF1R mutation and leukodystrophy at brain MRI) - Presymptomatic patient adults (males or females) carrying CSF1R mutations (PRE-ALSP) - Children (15 months-18 years) without neurologic disease (no obvious neurological symptoms, normal neurologic examination) - Adults aged between 18 and 60 years without neurologic disease (no overt neurological symptoms) - willing to sign a consent form obtained : - from the parents or guardian for children patients and children controls; - from subject himself for adult patients and adult controls. Who Should NOT Join This Trial: - Participation to a therapeutic clinical trial - Treatment likely to modify the immune system - Unable to have a blood collection (i.e. low hemoglobin level at the investigator's judgment) - Any other reason, to the discretion of the investigator - Children or adults without health insurance or social security Always talk to your doctor about whether this trial is right for you.