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RECRUITINGOBSERVATIONAL

Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort

Global Collaborative Research on Establishing a Korean Cognitive Aging Cohort That is Associated With the Einstein Aging Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this observational study is to learn how daily emotional stress affects cognitive function and inflammation in community-dwelling older adults aged 60 and older in Seoul, Republic of Korea. The main questions it aims to answer are: Does daily psychological stress measured in real-time affect short-term and long-term cognitive function in older adults? Do pro-inflammatory cytokines (such as CRP, IL-6, IL-10, and TNF-α) mediate the relationship between emotional stress and cognitive decline? How do social support and social isolation influence cognitive function and inflammatory biomarkers over time? Participants will: Complete baseline surveys assessing depression, cognitive function, and personal characteristics Use a smartphone app to answer brief surveys about their emotions, cognitive performance, and social interactions 1-6 times daily for two weeks Wear a Galaxy Watch to track sleep quality, heart rate, and physical activity Provide blood samples for inflammatory biomarker analysis Return for follow-up assessments at 6 months and 1 year This study is part of an international collaboration to establish a Korean cohort comparable to the U.S. Einstein Aging Study, with the aim of developing culturally tailored dementia prevention strategies.

Who May Be Eligible (Plain English)

Who May Qualify: - Adults aged 60 or older residing in the Republic of Korea - Samsung Galaxy smartphone users capable of using smartphone applications - Sufficient cognitive ability to understand and follow research instructions (MMSE score of 21 or above) - For individuals who do not meet the cognitive criteria, those who understand the study procedures and provide willing to sign a consent form along with their legal guardian Who Should NOT Join This Trial: - Diagnosis of dementia at baseline - Severe visual or hearing impairments that prevent participation in psychological assessments - Illiteracy that prevents participation in cognitive testing - Less than 80% compliance with the 2-day preliminary EMA protocol (one additional attempt allowed after re-training) - Current alcohol or substance abuse - Inability to ambulate or psychiatric conditions that prevent survey participation - Currently undergoing cancer treatment or received chemotherapy within the past 6 months Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Adults aged 60 or older residing in the Republic of Korea * Samsung Galaxy smartphone users capable of using smartphone applications * Sufficient cognitive ability to understand and follow research instructions (MMSE score of 21 or above) * For individuals who do not meet the cognitive criteria, those who understand the study procedures and provide informed consent along with their legal guardian Exclusion Criteria: * Diagnosis of dementia at baseline * Severe visual or hearing impairments that prevent participation in psychological assessments * Illiteracy that prevents participation in cognitive testing * Less than 80% compliance with the 2-day preliminary EMA protocol (one additional attempt allowed after re-training) * Current alcohol or substance abuse * Inability to ambulate or psychiatric conditions that prevent survey participation * Currently undergoing cancer treatment or received chemotherapy within the past 6 months

Locations (1)

Korea University
Seoul, Select One..., South Korea