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RECRUITINGINTERVENTIONAL

Aqueous Humor and Ocular Tissue Analysis in Glaucoma and Cataract

Integrated Chemical and Proteomic Analysis of Aqueous Humor and Ocular Tissues in Glaucoma and Cataract Patients

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This observational study will compare proteomic and elemental profiles of aqueous humor and ocular tissues in patients with primary open-angle glaucoma (POAG) and cataract versus cataract controls without glaucoma. Samples collected during standard surgery will be analyzed using LC-MS/MS and ICP-MS. The goal is to identify glaucoma-associated molecular patterns with potential diagnostic or prognostic relevance.

Who May Be Eligible (Plain English)

Who May Qualify: - Age ≥ 18 years. - Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation). - Ability to provide written willing to sign a consent form. - For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure. - For control arm: cataract without glaucoma and without other significant ocular pathology. Who Should NOT Join This Trial: - Age \< 18 years. - Pregnancy or breastfeeding. - Advanced visual impairment in the study eye (visual aquity worse than counting fingers). - Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma). - History of intraocular surgery in the study eye (including glaucoma surgery), vitreoretinal surgery, corneal transplantation, or refractive surgery. - Active or previous uveitis. - Other significant chronic ocular disease in the study eye (other than cataract and POAG in the glaucoma arm). - Inability to comply with study procedures or follow-up visits. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age ≥ 18 years. * Scheduled for cataract surgery (phacoemulsification with intraocular lens implantation). * Ability to provide written informed consent. * For glaucoma arm: diagnosis of primary open-angle glaucoma (POAG) with coexisting cataract, and planned combined cataract surgery with glaucoma procedure. * For control arm: cataract without glaucoma and without other significant ocular pathology. Exclusion Criteria: * Age \< 18 years. * Pregnancy or breastfeeding. * Advanced visual impairment in the study eye (visual aquity worse than counting fingers). * Any glaucoma type other than primary open-angle glaucoma (e.g., angle-closure, secondary, neovascular glaucoma). * History of intraocular surgery in the study eye (including glaucoma surgery), vitreoretinal surgery, corneal transplantation, or refractive surgery. * Active or previous uveitis. * Other significant chronic ocular disease in the study eye (other than cataract and POAG in the glaucoma arm). * Inability to comply with study procedures or follow-up visits.

Treatments Being Tested

PROCEDURE

Phacoemulsification With Intraocular Lens Implantation and Deep Sclerectomy

Standard-of-care combined cataract surgery (phacoemulsification with intraocular lens implantation) performed together with deep sclerectomy for glaucoma management. Intraoperative collection of aqueous humor and routinely removed ocular tissues (such as sclera and anterior lens capsule) is performed for research analyses.

PROCEDURE

Phacoemulsification With Intraocular Lens Implantation

Standard-of-care cataract surgery (phacoemulsification with intraocular lens implantation). Intraoperative collection of aqueous humor and routinely removed ocular tissue (anterior lens capsule) is performed for research analyses.

Locations (2)

Military Institute of Medicine - National Research Institute
Warsaw, Poland
University of Warsaw
Warsaw, Poland