Effect of COV2 Vaccine Formulation on the Ability to Generate Antibodies Against Coronavirus That Causes COVID-19

Inclusion criteria * Has voluntarily signed the written informed consent * Male or female aged ≥18 to ≤75 years * Good general health based upon the results of the medical history, laboratory tests, physical examination, ENT clinical examination, and vital signs as assessed by the investigator * Prior vaccination with at least two doses of any COVID-19 vaccine with last dose obtained ≥180 days before the planned baseline (Day 0) visit * Has a personal smartphone, tablet or computer with internet access, and is considered willing and able to report the data in the ePRO and to comply with the reporting timelines * Willing and able to comply with the instructions to participants * Not of childbearing potential or willing and able to use a highly effective contraception method consistently and correctly during the entire trial Exclusion criteria * Pregnant, planning to become pregnant, or breastfeeding women * Received any investigational drug \< 180 days prior baseline * Antigen positivity or PCR confirmed SARS-CoV-2 infection less than 180 days apart from screening or during screening and/or baseline * Any SARS-CoV vaccination was administrated \< 180 days prior the planned baseline (Day 0) visit * Any other vaccination within 60 days prior the planned baseline (Day 0) visit * Administration of immunoglobulins or blood products within 90 days prior baseline * Current use of immunosuppressant medication (except topical and inhaled steroids, which are permitted in indications not prohibited in the exclusion criteria) * Use of steroid nasal sprays within 30 days prior to screening * Use of any oral or nasal decongestants within 7 days prior to screening * Any confirmed or suspected immunodeficient state * Chronic respiratory diseases (except treatment -controlled asthma) * Severe chronic cardiovascular and endocrinological diseases (e.g., medicine or insulin treated diabetes), liver and renal insufficiency or serious psychiatric diseases \- Medication for elevated cholesterol or blood pressure or dietary treated diabetes or hypothyreosis are not exclusion criteria * Any diagnosed disease or abnormality in the nasal or upper respiratory tract, such as acute/chronic rhinosinusitis; nasal polyposis; mucosal pathology or tumor of nasal cavity, pharynx or nasopharynx; significant obstructive nasal deformity; recurrent epistaxis; sleep apnea; anosmia \- History of adenoidectomy and/or tonsillectomy are not exclusion criteria * Severe obesity (BMI ≥ 35) * Cancer treated within 5 years * Known allergy/hypersensitivity to any ingredients of the COV2 vaccine * Previous anaphylactic reaction * Any clinically significant abnormal finding in the screening laboratory tests * Inability to sign ICF or to understand and comply with trial related instructions and requirements * Individuals who are employees of, or directly affiliated with, the sponsor, or site staff or their immediate family members.