RECRUITINGINTERVENTIONAL
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
A Comparative Study of In Vitro Fertilization Outcomes Between PPOS and Antagonist Protocols in Women With Polycystic Ovary Syndrome
About This Trial
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
Who May Be Eligible (Plain English)
Who May Qualify:
- Women aged 18-40 years
- Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound)
- Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI)
- Eligible for controlled ovarian stimulation for IVF
- Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT)
- Willing and able to provide written willing to sign a consent form and comply with study procedures.
Who Should NOT Join This Trial:
- Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology.
- History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy)
- History of recurrent pregnancy loss (≥3 spontaneous miscarriages)
- Known chromosomal abnormalities in either partner
- Inability to adhere to study protocol or follow-up procedures
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Women aged 18-40 years
* Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound)
* Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI)
* Eligible for controlled ovarian stimulation for IVF
* Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT)
* Willing and able to provide written informed consent and comply with study procedures.
Exclusion Criteria:
* Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology.
* History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy)
* History of recurrent pregnancy loss (≥3 spontaneous miscarriages)
* Known chromosomal abnormalities in either partner
* Inability to adhere to study protocol or follow-up procedures
Treatments Being Tested
DRUG
Progestin-Primed Ovarian Stimulation (PPOS)
Ovarian stimulation using a progestin-primed ovarian stimulation (PPOS) protocol, including gonadotropins combined with oral progestin for pituitary suppression during in vitro fertilization treatment.
DRUG
GnRH Antagonist Protocol
Ovarian stimulation using a gonadotropin-releasing hormone (GnRH) antagonist protocol for pituitary suppression during in vitro fertilization treatment.
Locations (1)
Hanoi General Hospital
Hanoi, Hanoi, Vietnam