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RECRUITINGINTERVENTIONAL

Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS

A Comparative Study of In Vitro Fertilization Outcomes Between PPOS and Antagonist Protocols in Women With Polycystic Ovary Syndrome

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.

Who May Be Eligible (Plain English)

Who May Qualify: - Women aged 18-40 years - Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound) - Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI) - Eligible for controlled ovarian stimulation for IVF - Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT) - Willing and able to provide written willing to sign a consent form and comply with study procedures. Who Should NOT Join This Trial: - Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology. - History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy) - History of recurrent pregnancy loss (≥3 spontaneous miscarriages) - Known chromosomal abnormalities in either partner - Inability to adhere to study protocol or follow-up procedures Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Women aged 18-40 years * Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound) * Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI) * Eligible for controlled ovarian stimulation for IVF * Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT) * Willing and able to provide written informed consent and comply with study procedures. Exclusion Criteria: * Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology. * History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy) * History of recurrent pregnancy loss (≥3 spontaneous miscarriages) * Known chromosomal abnormalities in either partner * Inability to adhere to study protocol or follow-up procedures

Treatments Being Tested

DRUG

Progestin-Primed Ovarian Stimulation (PPOS)

Ovarian stimulation using a progestin-primed ovarian stimulation (PPOS) protocol, including gonadotropins combined with oral progestin for pituitary suppression during in vitro fertilization treatment.

DRUG

GnRH Antagonist Protocol

Ovarian stimulation using a gonadotropin-releasing hormone (GnRH) antagonist protocol for pituitary suppression during in vitro fertilization treatment.

Locations (1)

Hanoi General Hospital
Hanoi, Hanoi, Vietnam