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RECRUITINGOBSERVATIONAL

Salivary Cortisol Levels in Children With Molar Incisor Hypomineralization

Evaluation of Salivary Cortisol Levels and Physiological Stress Parameters in Children With Molar Incisor Hypomineralization: A Comparative Observational Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Molar incisor hypomineralization (MIH) is a developmental condition that affects the enamel of permanent molars and incisors in children and may cause tooth sensitivity, discomfort, and difficulties during dental treatment. These problems can increase dental anxiety and lead to physiological stress responses during dental visits. The purpose of this observational study is to evaluate physiological stress responses in children with MIH by measuring salivary cortisol levels, heart rate, and oxygen saturation, and to compare these findings with those of children without MIH. A total of 90 children aged 8 to 12 years will participate in the study, including 45 children diagnosed with MIH and 45 healthy control participants. Participation involves no treatment or intervention beyond a routine clinical dental examination. Heart rate and oxygen saturation will be measured during the dental visit, and saliva samples will be collected immediately after the examination using a non-invasive method to assess cortisol levels. The results of this study may contribute to a better understanding of stress responses in children with MIH and support the development of more individualized and anxiety-sensitive dental care approaches.

Who May Be Eligible (Plain English)

Who May Qualify: - Children aged between 8 and 12 years. - Children diagnosed with molar incisor hypomineralization (MIH) according to the European Academy of Paediatric Dentistry (EAPD) criteria or healthy children without MIH. - Ability to cooperate sufficiently to complete the clinical dental examination and study procedures. - Written willing to sign a consent form obtained from a parent or legal guardian. Who Should NOT Join This Trial: - Presence of systemic, hormonal, or metabolic diseases. - Regular use of medications known to affect salivary cortisol levels or cardiovascular parameters (e.g., corticosteroids, beta-blockers). - History of systemic conditions that may influence stress response. - Refusal of participation by the child or parent/legal guardian. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Children aged between 8 and 12 years. * Children diagnosed with molar incisor hypomineralization (MIH) according to the European Academy of Paediatric Dentistry (EAPD) criteria or healthy children without MIH. * Ability to cooperate sufficiently to complete the clinical dental examination and study procedures. * Written informed consent obtained from a parent or legal guardian. Exclusion Criteria: * Presence of systemic, hormonal, or metabolic diseases. * Regular use of medications known to affect salivary cortisol levels or cardiovascular parameters (e.g., corticosteroids, beta-blockers). * History of systemic conditions that may influence stress response. * Refusal of participation by the child or parent/legal guardian.

Locations (1)

Lokman Hekim University, Faculty of Dentistry
Ankara, Ankara, Turkey (Türkiye)