LDA and LMWH vs LDA Alone in High-risk Patients for Preeclampsia Prevention

Who May Qualify: - Singleton pregnancy - High risk for preeclampsia (risk \>1:150) based on FMF screening algorithm combining first-trimester ultrasound, biochemical markers, and medical history - Gestational age \<16 weeks at enrollment - Maternal age ≥18 years - Willing and able to provide written willing to sign a consent form - Adequate ability for follow-up (direct telephone communication, accessible residence) Who Should NOT Join This Trial: - Multiple pregnancy - Current permanent aspirin use for other medical indications - Serious congenital fetal abnormality detected on ultrasound - Contraindication to aspirin or low molecular weight heparin including: known hypersensitivity, active peptic ulcer disease, bleeding disorders or coagulopathy, severe thrombocytopenia (platelet count \<100,000/μL), active or recent significant bleeding, history of heparin-induced thrombocytopenia - Pre-existing severe renal failure (creatinine clearance \<30 mL/min) - Unable to provide willing to sign a consent form - Low probability of adequate follow-up (residence in remote areas without telephone access, accommodation in temporary structures) Always talk to your doctor about whether this trial is right for you.