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RECRUITINGOBSERVATIONAL

Landscape of Gout in French Polynesia.

FENUA-METABOGOUT : Genetic Landscape of Gout, Inflammation and Metabolic Diseases in French Polynesia.

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The aim of this research is to characterise the genetic and molecular landscape of gout, inflammation and metabolic diseases, as well as the associated molecular, anthropomorphic and pathological characteristics.

Who May Be Eligible (Plain English)

Who May Qualify: All participants: - Age between 18 and 75 years old inclusive - Signature of willing to sign a consent form - Fasting for the collection of biological samples - Declared Polynesian ancestry - Affiliated to a social security scheme General population group : - Not having participated to the 2021 TOPATA study - Visiting a general practitioner (for whatever reason) Gout Group : - Managed at the rheumatology clinic of the Taaone Hospital Centre (CHT) in Papeete by Dr Baptiste Gérard. Tophaceous gout sub-group: - Present with tophaceous gout. Gout crisis subgroup: - Be within 48 hours of the onset of a gout attack - Agree to return 1 week after inclusion for the second blood and urine sample. 2021 follow-up group: - To have been included in the TOPATA study in 2021 - Have taken the genetic and biological samples that generated the genetic and serum urate data for the 2021 study - Have hyperuricaemia without signs of gout OR without hyperuricaemia or gout at the time of inclusion in TOPATA Who Should NOT Join This Trial: All participants : - Refusal or inability to understand or give consent - Physical inability to follow and respect the protocol - 1st degree relative\*, - Person under guardianship or trusteeship - Pregnant or breast-feeding woman \* If several relatives from the same household are eligible to participate, only one person may be included in the study. The choice is left to the discretion of the investigator or the first person met. However, both members of a couple (e.g. husband and wife) may participate. - General population group : - Unable to return for sampling if required. - Gout group : - Person wearing a knee prosthesis - People suffering from other inflammatory rheumatic diseases Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: All participants: * Age between 18 and 75 years old inclusive * Signature of informed consent * Fasting for the collection of biological samples * Declared Polynesian ancestry * Affiliated to a social security scheme General population group : * Not having participated to the 2021 TOPATA study * Visiting a general practitioner (for whatever reason) Gout Group : * Managed at the rheumatology clinic of the Taaone Hospital Centre (CHT) in Papeete by Dr Baptiste Gérard. Tophaceous gout sub-group: * Present with tophaceous gout. Gout crisis subgroup: * Be within 48 hours of the onset of a gout attack * Agree to return 1 week after inclusion for the second blood and urine sample. 2021 follow-up group: * To have been included in the TOPATA study in 2021 * Have taken the genetic and biological samples that generated the genetic and serum urate data for the 2021 study * Have hyperuricaemia without signs of gout OR without hyperuricaemia or gout at the time of inclusion in TOPATA Exclusion Criteria: All participants : * Refusal or inability to understand or give consent * Physical inability to follow and respect the protocol * 1st degree relative\*, * Person under guardianship or trusteeship * Pregnant or breast-feeding woman \* If several relatives from the same household are eligible to participate, only one person may be included in the study. The choice is left to the discretion of the investigator or the first person met. However, both members of a couple (e.g. husband and wife) may participate. * General population group : * Unable to return for sampling if required. * Gout group : * Person wearing a knee prosthesis * People suffering from other inflammatory rheumatic diseases

Treatments Being Tested

OTHER

Epidemiological study

Collection of sociodemographic data, collection of treatment data, standard and clinical ophthalmological examination, physical and biological measurements, clinical characteristics specific to chronic and metabolic diseases, questionnaires (gout questionnaire, health assessment questionnaire (HAQ-II), EuroQol (EQ)-5D-5L, joint pain, state of health, diet and physical activity, access to care, addictions, sleep quality, pain scale (EVA), personal and family history) will be performed.

DIAGNOSTIC_TEST

Blood and urine tests

Collection of blood and urine samples for genetic, biochemical, omics, and biobank analyses, in order to characterize cardiometabolic health markers will be performed.

Locations (6)

Medical Office Dr Antoine Scuiller
Faa'a, French Polynesia
Medical Office Dr Cedric Gueguen
Papeete, French Polynesia
Medical Office Dr Voradeth Nouanesengsy
Papeete, French Polynesia
CH de Polynesie Française Papeete
Pirae, French Polynesia
Medical Office Dr Nanethida Nouanesengsy
Pirae, French Polynesia
Medical Office Dr Raphael Habib
Pirae, French Polynesia