RECRUITINGOBSERVATIONAL
Familial Systemic Scleroderma
About This Trial
Studying familial forms of systemic scleroderma offers several advantages: 1. To better understand the pathophysiology of a complex autoimmune disease based on "extreme" cases (familial forms); 2. To identify potential molecular markers predictive of disease progression; 3. To identify potential pathophysiological targets for developing new therapies, particularly relevant in severe and refractory forms of the disease.
Who May Be Eligible (Plain English)
Who May Qualify:
- Adult subjects (≥ 18 years of age)
- Subjects diagnosed with systemic scleroderma by a clinician (including limited, diffuse, and sine scleroderma SSc, as well as overlap syndromes with myositis) and meeting at least the VEDOSS criteria: Raynaud's phenomenon + 1 other criterion from among: sausage fingers, antinuclear antibodies, scleroderma-specific antibodies (anti-centromere, anti-RNApolIII, anti-ScL70), capillaroscopic abnormalities
- At least one first-degree relative with systemic scleroderma meeting the same criteria
Who Should NOT Join This Trial:
\- Subject who has expressed opposition to participating in the study
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Adult subjects (≥ 18 years of age)
* Subjects diagnosed with systemic scleroderma by a clinician (including limited, diffuse, and sine scleroderma SSc, as well as overlap syndromes with myositis) and meeting at least the VEDOSS criteria: Raynaud's phenomenon + 1 other criterion from among: sausage fingers, antinuclear antibodies, scleroderma-specific antibodies (anti-centromere, anti-RNApolIII, anti-ScL70), capillaroscopic abnormalities
* At least one first-degree relative with systemic scleroderma meeting the same criteria
Exclusion Criteria:
\- Subject who has expressed opposition to participating in the study
Locations (1)
Service de Médecine interne et Immunologie clinique - CHU de Strasbourg - France
Strasbourg, France