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RECRUITINGINTERVENTIONAL

A Physiotherapy Intervention Study in Patients With Amyotrophic Lateral Sclerosis (ALS)

Individualized Physiotherapy Addressing Patient-Specific Deficits in Amyotrophic Lateral Sclerosis Compared to Usual Care Physiotherapy: A Prospective, Pseudorandomized, Controlled, Interventional Study

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This study investigates whether an individualized physiotherapy program, tailored to each patient's specific motor deficits, can better support physical function compared with usual care physiotherapy in people with ALS. The individualized program is guided by diagnostic assessments using a robotic leg press system, which helps identify strengths and weaknesses in muscle function and movement control. Participants will receive either individualized physiotherapy or standard physiotherapy and will be followed for 12 months. The aim of the study is to improve physiotherapy strategies for people with ALS in a safe and patient-centered manner.

Who May Be Eligible (Plain English)

Who May Qualify: - diagnosis of clinically probable, probable laboratory-supported, or definite ALS (revised El Escorial criteria) or upper motor neuron only (OPM classification \[onset, propagation, motoneuron involvement\]) - age ≥18 years; ability to understand study information and provide written willing to sign a consent form - Willingness and ability to perform individualized exercise according to the study protocol (approximately three to five sessions of 30 minutes per week) for the duration of the intervention period - Individuals of all sexes and gender identities are eligible for inclusion Who Should NOT Join This Trial: - pregnancy, tracheostomy, continuous assisted ventilation, or other significant non-ALS pulmonary disease - other neurodegenerative or neuromuscular conditions that may confound assessments - concomitant life-threatening disease or impairment interfering with functional assessment Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * diagnosis of clinically probable, probable laboratory-supported, or definite ALS (revised El Escorial criteria) or upper motor neuron only (OPM classification \[onset, propagation, motoneuron involvement\]) * age ≥18 years; ability to understand study information and provide written informed consent * Willingness and ability to perform individualized exercise according to the study protocol (approximately three to five sessions of 30 minutes per week) for the duration of the intervention period * Individuals of all sexes and gender identities are eligible for inclusion Exclusion Criteria: * pregnancy, tracheostomy, continuous assisted ventilation, or other significant non-ALS pulmonary disease * other neurodegenerative or neuromuscular conditions that may confound assessments * concomitant life-threatening disease or impairment interfering with functional assessment

Treatments Being Tested

OTHER

Individualized Physiotherapy

see above

Locations (1)

ALS Clinic
Sankt Gallen, Switzerland