RECRUITINGOBSERVATIONAL
SAS 1: Develop Ocular Disease (OSD) Diagnostic, Algorithms, and Management Protocols for Cataract Surgery
About This Trial
Patient: Tear film issues resulting in poor visual outcomes are a major cause of dissatisfaction after cataract surgery. There is no universal best preoperative algorithm for managing the ocular surface prior to surgery. Industry: Recent advances in tear/cornea imaging and refractive cataract surgery such as multifocal intraocular lenses will be advantageous to patients only if tear film issues can be addressed. Society: Cataract surgery is the most common ophthalmic surgery done in Singapore and worldwide. Improving vision by attending to tear film problems improves quality of life.
Who May Be Eligible (Plain English)
Who May Qualify:
- Inclusion criteria for dry eye (participant must meet at least 1 of the inclusion criteria below):
1. Symptomatic for dry eye based on DEQ5 (\>6) and \[either TBUT less than 5 s or staining \>grade 1 in any zone of the cornea\]
2. Either use of diquasfosol, cyclosporine eyedrops or tacrolimus eyedrops for dry eye disease in the last 2 weeks (and previously started for more than 2 months), OR current and visible lower punctal plugs in at least one eye
Inclusion criteria to fulfil all for controls (patients w/o dry eye):
1. DEQ5 \<=6.
2. Staining \< grade 1 in at least one corneal zone.
3. Not using diquasfosol, cyclosporine, tacrolimus in last 2 months.
4. No visible punctal plugs.
Who Should NOT Join This Trial:
- If there is another ocular condition which affects vision as much as cataract: active corneal stromal disease or scar or significant corneal endothelial disease
- Known diagnosis of active thyroid dysfunction, Sjogren disease and rheumatoid arthritis
- Intraocular surgery within the previous 6 months
- Laser-assisted in situ keratomileusis or pterygium surgery within the previous 3 months
- Central nervous system and hormonal drugs required within the last month and during the study
- Active ocular infection, inflamed chalazion, or presence of pterygium
- Glaucoma which requires topical anti-glaucoma medications
- Any need to wear contact lens during the study
- Having issues which make it difficult to follow up (eg., wheelchair, etc)
- Pregnant and breast-feeding woman
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Inclusion criteria for dry eye (participant must meet at least 1 of the inclusion criteria below):
1. Symptomatic for dry eye based on DEQ5 (\>6) and \[either TBUT less than 5 s or staining \>grade 1 in any zone of the cornea\]
2. Either use of diquasfosol, cyclosporine eyedrops or tacrolimus eyedrops for dry eye disease in the last 2 weeks (and previously started for more than 2 months), OR current and visible lower punctal plugs in at least one eye
Inclusion criteria to fulfil all for controls (patients w/o dry eye):
1. DEQ5 \<=6.
2. Staining \< grade 1 in at least one corneal zone.
3. Not using diquasfosol, cyclosporine, tacrolimus in last 2 months.
4. No visible punctal plugs.
Exclusion Criteria:
* If there is another ocular condition which affects vision as much as cataract: active corneal stromal disease or scar or significant corneal endothelial disease
* Known diagnosis of active thyroid dysfunction, Sjogren disease and rheumatoid arthritis
* Intraocular surgery within the previous 6 months
* Laser-assisted in situ keratomileusis or pterygium surgery within the previous 3 months
* Central nervous system and hormonal drugs required within the last month and during the study
* Active ocular infection, inflamed chalazion, or presence of pterygium
* Glaucoma which requires topical anti-glaucoma medications
* Any need to wear contact lens during the study
* Having issues which make it difficult to follow up (eg., wheelchair, etc)
* Pregnant and breast-feeding woman
Locations (1)
Singapore Eye Research Institute
Singapore, Singapore