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RECRUITINGINTERVENTIONAL

Phonological Constraints on Language Development in Individuals With Williams Syndrome

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Williams syndrome (WS) is a neurodevelopmental disease characterized by mild to moderate intellectual disability and an extremely heterogeneous cognitive profile. Research has outlined two main features of WS: an atypical social behavior associated with surprising language abilities, and a hyperacusis. The purpose of this project is to investigate the relationships between both these abilities, and particularly the role of the hyperacusis on language abilities. The hyperacusis would be crucial in developing language skills: the apparent strength in the verbal domain could rely on Phonological Short Term Memory (PSTM) more in individuals with WS than in typically developing individuals. In addition, the investigators will compare individuals with WS to individuals with Down syndrome (DS): DS is often associated to strong limitations in the PSTM with poor language abilities. To this end, the investigators will use a highly innovative approach including physiological assessments (EEG-NIRS protocol) and questionnaires. The performance of people with WS will be compared to those of participants with DS and TD participants of same DA and cognitive assessments.

Who May Be Eligible (Plain English)

Who May Qualify: - For SW and SD: genetic diagnosis and aged between 6- and 17 years old. - For typical participants: any child, adolescent or young adult of the same developmental or chronological age (between 6 and 17 years of age) - adult group (between 20 and 60 years). Who Should NOT Join This Trial: - Autistic Associated Disorders, - West syndrome Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * For SW and SD: genetic diagnosis and aged between 6- and 17 years old. * For typical participants: any child, adolescent or young adult of the same developmental or chronological age (between 6 and 17 years of age) * adult group (between 20 and 60 years). Exclusion Criteria: * Autistic Associated Disorders, * West syndrome

Treatments Being Tested

OTHER

EEG-NIRS protocol

Each participant will be tested individually in a quiet room at the GRAMFC (Groupe de Recherches sur l'Analyse Multimodale de la Fonction Cérébrale, INSERM-UMR1105, Université Picardie Jules Verne and CHU Amiens-Picardie). Duration of subject's participation in the study is 120 minutes

OTHER

Questionnaire

Each participant will be tested individually in a quiet room at the GRAMFC (Groupe de Recherches sur l'Analyse Multimodale de la Fonction Cérébrale, INSERM-UMR1105, Université Picardie Jules Verne and CHU Amiens-Picardie). Duration of subject's participation in the study is 120 minutes

Locations (1)

CHU Amiens
Amiens, France