Development of a Quantifiable Ultrasound Biomarker for Hepatic Steatosis

Who May Qualify: Diseased subject: - Adult patients (age 18 - 75 years) - Consent to participate in the study - Diagnosed or suspected MASLD from the hepatology clinic, OR - High-risk population meeting the adult cardiometabolic criteria (defined as the presence of at least one of the following: diabetes, obesity (BMI ≥ 25 kg/m2), hypercholesterolemia, and hypertension) Healthy volunteer: - Adult patients (age 18 - 75 years) - Consent to participate in the study - No suspicion of MASLD by laboratory/imaging/clinical examinations - Absence of known pre-existing conditions (metabolic syndrome, diabetes mellitus, obesity, insulin resistance, dyslipidemia, etc.) Who Should NOT Join This Trial: - Pregnancy or nursing. - Contraindications to MRI including, but not limited to, severe claustrophobia, pacemaker, or existing metallic/mechanical implant(s). - Acute illness/cognitive impairment resulting in an inability to cooperate with the MRI and ultrasound breath-holding instructions. - BMI \> 35 kg/m2 - History of excessive alcohol consumption according to the updated MASLD criteria (\>2 drinks/day OR \>210 grams/week for males AND \>1 drink/day OR \>140 grams/week for females) or drug use over the past 2 years. - Known acute or chronic hepatitis; or other etiology of liver disease. - Presence of known congenital hepatic anomaly. - Known cirrhosis - Known active cancer Always talk to your doctor about whether this trial is right for you.