Impact of TRYPTYR on a Patient's Quality of Life and Ability to Perform Work

Who May Qualify: - Adults ≥18 years of age. - Have a history of DED for at least the past 6 months. - Are currently using Restasis as directed by their eye care provider for ≥1 month. - Participant intends to stop Restasis in the near future because and expressed dissatisfaction with effectiveness of Restasis in reducing dry eye symptoms.. - Are symptomatic as determined with the Eye Dryness visual analog scale (VAS) (Score ≥50), SPEED (≥7), and have an abnormal Schirmer test score \[≥2 to \<10 mm/5 min\]) at Screening/Baseline. - Have corrected distance visual acuity of 20/100 or better. - Willing to discontinue contact lens wear throughout the study. Who Should NOT Join This Trial: - Have a systemic health condition that is known to alter tear film physiology (e.g., primary and secondary Sjögren's syndrome). - Have a history of ocular surgery within the past 12 months. - Have a history of severe ocular trauma, active ocular infection or inflammation that is not dry eye related. - Punctal plugs in place for \< 3 months and/or Lacrifill in place for \> 5 months. - Have ever used Accutane or are currently using ocular medications (must washout from all dry eye medications/treatments at least 1 week before entry, except for Restasis). - Use of artificial tears within 2 hours prior to the baseline visit or during the study. - Are pregnant or breast feeding. - Have had a physical meibomian gland treatment withing 1 month of enrollment. - Have a condition or be in a situation, which in the investigator's opinion, may put the participant at significant risk, may confound the results, or may significantly interfere with their study participation. Always talk to your doctor about whether this trial is right for you.