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RECRUITINGOBSERVATIONAL

Transcriptomic Study of Cutaneous Fibroblasts in Scleroderma

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Scleroderma is a complex connective tissue disease involving three interconnected pathophysiological axes: vascular hyperactivity and remodelling, immune system dysfunction and over-activation of fibroblasts at the origin of the fibrosis process in the skin and organs. Given that this pathology occurs preferentially in mature subjects, it is possible to suggest a potential inductive role for senescent fibroblasts, which would be responsible for activating and/or maintaining the immune response and systemic inflammation. Our hypothesis is that fibroblasts play a predominant role in the genesis and maintenance of this pathology.

Who May Be Eligible (Plain English)

Who May Qualify: FOR PATIENTS WITH SCLERODERMA : - Person who has given written consent - Person with systemic scleroderma FOR CONTROL PARTICIPANTS : - Person who has given written consent - Person undergoing plastic, cosmetic and reconstructive surgery Who Should NOT Join This Trial: FOR PATIENTS WITH SCLERODERMA : - Person not affiliated to or not benefiting from a social security scheme - Person subject to a legal protection measure (curatorship, guardianship) - Person subject to a legal protection measure - An adult who is incapable or unable to give consent - Minors FOR CONTROLLED PARTICIPANTS : - Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases - Person not affiliated to or not benefiting from a social security scheme - Person under legal protection (curatorship, guardianship) - Person subject to a legal protection measure - An adult who is incapable or unable to give consent - Minors Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: FOR PATIENTS WITH SCLERODERMA : * Person who has given written consent * Person with systemic scleroderma FOR CONTROL PARTICIPANTS : * Person who has given written consent * Person undergoing plastic, cosmetic and reconstructive surgery Exclusion Criteria: FOR PATIENTS WITH SCLERODERMA : * Person not affiliated to or not benefiting from a social security scheme * Person subject to a legal protection measure (curatorship, guardianship) * Person subject to a legal protection measure * An adult who is incapable or unable to give consent * Minors FOR CONTROLLED PARTICIPANTS : * Person suffering from a chronic disease or under chronic treatment for autoimmune, inflammatory or dermatological diseases * Person not affiliated to or not benefiting from a social security scheme * Person under legal protection (curatorship, guardianship) * Person subject to a legal protection measure * An adult who is incapable or unable to give consent * Minors

Treatments Being Tested

PROCEDURE

Skin samples

* Scleroderma group: skin biopsy for scleroderma patients * Control group: recovery of resected tissue from patients undergoing plastic, reconstructive and aesthetic surgery.

OTHER

Analysis of fibroblasts

Analysis of samples by RNA sequencing

Locations (1)

CHU Dijon Bourgogne
Dijon, France