Skip to main content
TrialFinder
TrialFinder is for informational purposes only and does not provide medical advice. Always talk to your doctor about whether a trial is right for you.
RECRUITINGPhase 2INTERVENTIONAL

A Study of DII235 in Adults With Elevated Lipoprotein(a)

A Multi-center, Randomized, Double-blind, Placebo-controlled, Parallel-group, Dose-finding Study to Evaluate Efficacy, Safety, and Tolerability of DII235 in Adults With Elevated Lipoprotein(a)

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The main purpose of this study is to determine the safety and efficacy of DII235 in adults with elevated lipoprotein(a).

Who May Be Eligible (Plain English)

Who May Qualify: - Signed willing to sign a consent form must be obtained prior to participation in the study. - Male or female participants 18 to 80 years of age (inclusive) at the screening. - Lp(a) ≥ 150 nmol/L at screening, measured at the central laboratory. - Participants with evidence of atherosclerotic cardiovascular disease and/or type 2 diabetes mellitus. Who Should NOT Join This Trial: - Severe renal dysfunction - Hepatic dysfunction - Malignancy within the last 5 years - Use of investigational medications as defined in the protocol - History or presence at screening of an underlying disease, or surgical, physical, medical, or psychiatric condition that, in the opinion of the Investigator, or sponsor if consulted, would potentially affect participant safety within the study or interfere with participating in or completing the study or with the interpretation of data Other protocol-defined inclusion/exclusion criteria may apply Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Signed informed consent must be obtained prior to participation in the study. * Male or female participants 18 to 80 years of age (inclusive) at the screening. * Lp(a) ≥ 150 nmol/L at screening, measured at the central laboratory. * Participants with evidence of atherosclerotic cardiovascular disease and/or type 2 diabetes mellitus. Exclusion Criteria: * Severe renal dysfunction * Hepatic dysfunction * Malignancy within the last 5 years * Use of investigational medications as defined in the protocol * History or presence at screening of an underlying disease, or surgical, physical, medical, or psychiatric condition that, in the opinion of the Investigator, or sponsor if consulted, would potentially affect participant safety within the study or interfere with participating in or completing the study or with the interpretation of data Other protocol-defined inclusion/exclusion criteria may apply

Treatments Being Tested

DRUG

DII235

Solution for injection

DRUG

Saline

solution for injection

Locations (20)

Parkway Medical Center
Birmingham, Alabama, United States
Heart Center Research Llc
Huntsville, Alabama, United States
Cardiology and Medicine Clinic PA
Little Rock, Arkansas, United States
National Heart Institute
Beverly Hills, California, United States
Alliance Clinical
Canoga Park, California, United States
Excel Medical Clinical Trials LLC
Boca Raton, Florida, United States
Zenith Clinical Research
Hollywood, Florida, United States
Jacksonville Center for Clinical Research
Jacksonville, Florida, United States
Flourish Res Acq LLC North Miami
Miami, Florida, United States
Inpatient Research Clinical LLC
Miami Lakes, Florida, United States
Inpatient Research Clinical LLC
Miami Lakes, Florida, United States
Ocala Cardiovascular Research
Ocala, Florida, United States
SEC Clinical Research
Pensacola, Florida, United States
Cardiology Partners Clinical Research Institute
Wellington, Florida, United States
Atlanta Heart Specialists LLC
Tucker, Georgia, United States
AMR Chicago
Oak Brook, Illinois, United States
CV Ins of the South
Lafayette, Louisiana, United States
Monroe Research Llc
West Monroe, Louisiana, United States
Metropolitan Cardiovascular Consultants Llc
Beltsville, Maryland, United States
Anderson Medical Research
Ft. Washington, Maryland, United States