Zilucoplan for Severe gMG Exacerbations

Who May Qualify: - Patient determined to have severe MG exacerbation (e.g. bulbar and/or respiratory symptoms requiring hospitalization, neck extension weakness) - MGFA class II - IVb - Male or female aged ≥18 - MG-ADL ≥6 in non-ocular domains - Serology - AChR antibody positive (or historically available data) - If female of child-bearing potential (i.e., not surgically sterile or post-menopausal defined as age \> 51 years without menses for ≥ 2 years), negative serum pregnancy test at screening - Women of child-bearing potential or men with sexual partners of childbearing potential must be willing to use an acceptable method of birth control for the duration of the study and for 40 days after the last dose of study drug therapy. Acceptable methods of birth control include abstinence, oral contraceptives, the contraceptive patch, intra-uterine device, the contraceptive ring, and or barrier contraception such as condoms with spermicide. - Completed or updated meningococcal vaccination or initiated meningococcal vaccination with appropriate antibiotic prophylaxis according to current USPI and ACIP guidelines Who Should NOT Join This Trial: - History of meningococcal disease - Participants requiring intubation prior to study start. - Recent significant infections which could have caused exacerbation e.g. sepsis and wound infections - Pregnancy or lactating - Recent surgery (\<4 weeks). Minor procedures/surgeries allowed at the discretion of the site principal investigator - Current use or known failure of C5 inhibitors in the previous 3 months - Initiation of plasma exchange or IVIG in the past 4 weeks - Participation in concurrent clinical trial with a therapeutic medication - Rituximab use in the previous 9 months - Any clinically significant condition or illness, which, in the opinion of the PI, would pose a risk to the subject or might confound the study Always talk to your doctor about whether this trial is right for you.