Integrative Diagnosis for SCD and Other RADs

Who May Qualify: - Patients sustaining a confirmed or suspected diagnosis of an hereditary rare hemolytic anemia: - Sickle cell disease - Thalassemic syndromes - Congenital dyserythropoietic anemia - Enzymopathy - Unstable Hemoblogin / Altered oxygen affinity - Hereditary stomatocytosis - Hereditary pyropoikilocytosis - Hereditary spherocytosis with severe anemia (\<8 g/dL) or inconclusive diagnosis: - Patient with chronic hemolytic anemia and red cell smear compatible, but with: - EMA binding test: inconclusive or negative - Genetic testing: no definitive diagnosis (VUS or no findings) - Not transplanted or undergoing gene therapy at the time of inclusion. Patients with graft failure without a new transplant may be included. Who Should NOT Join This Trial: - Carrier traits in autosomal recessive hereditary anemias Always talk to your doctor about whether this trial is right for you.