RECRUITINGINTERVENTIONAL

Effects of Long-term Remote Ischemic Preconditioning on Clinical Outcome in Patients With Acute Myocardial Infarction

About This Trial

At present, there are 290 million cardiovascular patients in China, including 11 million patients with coronary heart disease. Remote ischemic preconditioning(RIPC) may play an effective endogenous cardiac protection.This study will explore whether long-term use of RIPC in patients with AMI after PCI and non interventional therapy can reduce the incidence of major adverse cardiovascular cerebrovascular events(MACCE) and improve clinical outcomes and long-term prognosis.

Who May Be Eligible (Plain English)

Who May Qualify: - Patients with acute myocardial infarction were diagnosed in accordance with the criteria of the "Global Unified Definition of Fourth Myocardial Infarction" Who Should NOT Join This Trial: - The patients could not tolerate RIPC or RIPerC - Aortic dissection, coronary artery aneurysm, coronary artery fistula and other systemic organic diseases - The uncontrolled systolic blood pressure and diastolic blood pressure of severe hypertension were 180 mmHg and 120 mmHg respectively - severe liver dysfunction (bilirubin \> 20 mmol / L, prothrombin time \> 2.0 ratio) - Severe renal insufficiency (GFR \< 30 ml / min / 1.73 m2); - patients taking nicorandil and other drugs affecting microcirculation - pregnant Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Patients with acute myocardial infarction were diagnosed in accordance with the criteria of the "Global Unified Definition of Fourth Myocardial Infarction" Exclusion Criteria: * The patients could not tolerate RIPC or RIPerC * Aortic dissection, coronary artery aneurysm, coronary artery fistula and other systemic organic diseases * The uncontrolled systolic blood pressure and diastolic blood pressure of severe hypertension were 180 mmHg and 120 mmHg respectively * severe liver dysfunction (bilirubin \> 20 mmol / L, prothrombin time \> 2.0 ratio) * Severe renal insufficiency (GFR \< 30 ml / min / 1.73 m2); * patients taking nicorandil and other drugs affecting microcirculation * pregnant

Treatments Being Tested

OTHER

RIPerC

Each 40 minutes treatment time, 10 minutes as a cycle (cuff inflated to 200 mmHg and maintained for 5 minutes, then deflated for 5 minutes to start the next cycle), a total of 4 cycles

OTHER

RIPC

Each 40 minutes treatment time, 10 minutes as a cycle (cuff inflated to 200 mmHg and maintained for 5 minutes, then deflated for 5 minutes to start the next cycle), a total of 4 cycles

Locations (1)

Fuwai Central China Cardiovascular Hospital

Zhengzhou, Henan, China