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RECRUITINGINTERVENTIONAL

Advanced Dressings for CVC Infection Prevention in PICU

Use of Advanced Fixation Dressings in Reducing Central Venous Catheter-related Bloodstream Infections in a Paediatric Intensive Care Unit

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Randomised, single-blind clinical trial comparing chlorhexidine gluconate-impregnated transparent dressings versus conventional transparent dressings in the prevention of central venous catheter-related bloodstream infections (CVC-BSI) in paediatric patients admitted to a tertiary hospital PICU. Outcomes include incidence of BRCVC, catheter colonisation, dressing-related skin complications, and number of dressing changes.

Who May Be Eligible (Plain English)

Who May Qualify: - Admission to paediatric intensive care unit (PICU) - Central venous catheter placement (central or peripherally inserted) - willing to sign a consent form obtained from parent/legal guardian Who Should NOT Join This Trial: - Known immunological disorders - Neutropenia (\<500/mm³) - Pre-existing colonisation or infection with multidrug-resistant organisms Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Admission to paediatric intensive care unit (PICU) * Central venous catheter placement (central or peripherally inserted) * Informed consent obtained from parent/legal guardian Exclusion Criteria: * Known immunological disorders * Neutropenia (\<500/mm³) * Pre-existing colonisation or infection with multidrug-resistant organisms

Treatments Being Tested

DEVICE

3M™ Tegaderm™ Antimicrobial Transparent Dressing (chlorhexidine gluconate-impregnated)

Individually applied transparent dressing containing chlorhexidine gluconate (0.5-1 mg/cm²) for antimicrobial protection at the central venous catheter insertion site. The dressing maintains site visibility, reduces catheter manipulation frequency, and provides sustained release of chlorhexidine to lower colonisation and bloodstream infection risk.

DEVICE

Conventional transparent polyurethane dressing

Transparent polyurethane dressing without antimicrobial impregnation, applied at the central venous catheter insertion site. This dressing allows site inspection and is widely used in standard paediatric intensive care protocols but provides no antimicrobial activity.

Locations (1)

Hospital Universitario Virgen del Rocío - Hospital Infantil
Seville, Sevilla, Spain