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RECRUITINGPhase 4INTERVENTIONAL

Effect of Protocolized Magnesium Replacement on Mortality and Atrial Fibrillation in Critically Ill Patients

Effect of Protocolized Magnesium Replacement in Critically Ill Patients on Mortality and Atrial Fibrillation: the MAGNOLIA Randomized Controlled Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

In patients with critical illness, such as severe infections, heart attacks, or respiratory failure, most intensive care units (ICUs) measure magnesium levels and give supplemental doses of magnesium when levels are below certain targets. However, the best targets are unknown. The goal of this clinical trial is to study protocols for magnesium supplementation in people with critical illness, comparing a protocol with higher target level to a protocol with a lower target level. The main question this study aims to answer is whether magnesium supplementation protocols targeting a higher or lower level lead to better 30-day survival and less atrial fibrillation. Participants will not have to do any specific tasks, undergo any additional tests, or complete any surveys.

Who May Be Eligible (Plain English)

Who May Qualify: - Age 16 years or older - Admission orders written to a medical-surgical intensive care unit at a participating site - Magnesium replacement protocol ordered Who Should NOT Join This Trial: - Prior enrollment in or withdrawal from MAGNOLIA trial - Sustained ventricular tachycardia - Pre-eclampsia - Myasthenia gravis Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age 16 years or older * Admission orders written to a medical-surgical intensive care unit at a participating site * Magnesium replacement protocol ordered Exclusion Criteria: * Prior enrollment in or withdrawal from MAGNOLIA trial * Sustained ventricular tachycardia * Pre-eclampsia * Myasthenia gravis

Treatments Being Tested

DRUG

Magnesium sulfate administration

Magnesium sulfate is used in both arms for magnesium replacement.

DRUG

Magnesium oxide

In the higher-target arm, magnesium oxide 420mg po q12h x 2 is one of the options available for magnesium replacement when magnesium levels lie between 0.75 and 0.95mmol/L.

DRUG

Magnesium glucoheptonate

Magnesium glucoheptonate 30mL po q12h x 2 is an oral option for magnesium replacement in the higher-target arm.

Locations (5)

Lakeridge Health Ajax-Pickering
Ajax, Ontario, Canada
Lakeridge Health Oshawa
Oshawa, Ontario, Canada
Scarborough Centenary Hospital
Toronto, Ontario, Canada
Scarborough General Hospital
Toronto, Ontario, Canada
Scarborough Birchmount Hospital
Toronto, Ontario, Canada