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RECRUITINGPhase 4INTERVENTIONAL

Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.

Who May Be Eligible (Plain English)

Who May Qualify: • All adult patients (\>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission. Who Should NOT Join This Trial: - High clinical suspicion for Legionella pneumonia - Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice) - Antibiotics not for CAP - Pregnant women (based on clinical assessment as part of standard of care) - Severe CAP as defined by the ATS/IDSA criteria - Corrected QT prolongation (\> 440 ms in men and \> 460 ms in women) - Receiving a different antibiotic (e.g quinolones) - Admission \> 24 hours - Known to be a prisoner Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: • All adult patients (\>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission. Exclusion Criteria: * High clinical suspicion for Legionella pneumonia * Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice) * Antibiotics not for CAP * Pregnant women (based on clinical assessment as part of standard of care) * Severe CAP as defined by the ATS/IDSA criteria * Corrected QT prolongation (\> 440 ms in men and \> 460 ms in women) * Receiving a different antibiotic (e.g quinolones) * Admission \> 24 hours * Known to be a prisoner

Treatments Being Tested

DRUG

Doxycycline

Subjects will receive Doxycycline (orally or intravenously) in combination with beta-lactam therapy within 12 hours of hospital admission. Treatment duration will be 5-7 days.

DRUG

Azithromycin

Subjects will receive Azithromycin (orally or intravenously) in combination with beta-lactam therapy within 12 hours of hospital admission. Treatment duration will be 5-7 days.

Locations (5)

Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Mayo Clinic in Florida
Jacksonville, Florida, United States
Mayo Clinic Health System-Mankato
Mankato, Minnesota, United States
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Mayo Clinic Health System-La Crosse
La Crosse, Wisconsin, United States