RECRUITINGPhase 4INTERVENTIONAL
Azithromycin Versus Doxycycline in Hospitalized Adult Patients With Community Acquired Pneumonia Treated With Beta-lactams
About This Trial
The purpose of this study is to compare effectiveness and safety of Azithromycin versus Doxycycline in adult patients hospitalized with community acquired pneumonia (CAP) treated with Beta-lactams.
Who May Be Eligible (Plain English)
Who May Qualify:
• All adult patients (\>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission.
Who Should NOT Join This Trial:
- High clinical suspicion for Legionella pneumonia
- Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice)
- Antibiotics not for CAP
- Pregnant women (based on clinical assessment as part of standard of care)
- Severe CAP as defined by the ATS/IDSA criteria
- Corrected QT prolongation (\> 440 ms in men and \> 460 ms in women)
- Receiving a different antibiotic (e.g quinolones)
- Admission \> 24 hours
- Known to be a prisoner
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
• All adult patients (\>18 years old) admitted with CAP and receiving a beta-lactam antibiotic plus a form of atypical coverage (azithromycin or doxycycline) in the ED within 12 hours of admission.
Exclusion Criteria:
* High clinical suspicion for Legionella pneumonia
* Allergy or contraindication to the use of either azithromycin or doxycycline (usual clinical practice)
* Antibiotics not for CAP
* Pregnant women (based on clinical assessment as part of standard of care)
* Severe CAP as defined by the ATS/IDSA criteria
* Corrected QT prolongation (\> 440 ms in men and \> 460 ms in women)
* Receiving a different antibiotic (e.g quinolones)
* Admission \> 24 hours
* Known to be a prisoner
Treatments Being Tested
DRUG
Doxycycline
Subjects will receive Doxycycline (orally or intravenously) in combination with beta-lactam therapy within 12 hours of hospital admission. Treatment duration will be 5-7 days.
DRUG
Azithromycin
Subjects will receive Azithromycin (orally or intravenously) in combination with beta-lactam therapy within 12 hours of hospital admission. Treatment duration will be 5-7 days.
Locations (5)
Mayo Clinic in Arizona
Scottsdale, Arizona, United States
Mayo Clinic in Florida
Jacksonville, Florida, United States
Mayo Clinic Health System-Mankato
Mankato, Minnesota, United States
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Mayo Clinic Health System-La Crosse
La Crosse, Wisconsin, United States