RECRUITINGPhase 3INTERVENTIONAL
OCEAN(a)-PreEvent - Olpasiran Trials of Cardiovascular Events And LipoproteiN(a) Reduction to Prevent First Major Cardiovascular Events
A Double-blind, Randomized, Placebo-controlled, Multicenter Study Assessing Olpasiran Use to Prevent First Major Cardiovascular Events in Participants With Elevated Lipoprotein(a)
About This Trial
The primary objective is to evaluate the effect of olpasiran, compared to placebo, on the risk for coronary heart disease death (CHD death), myocardial infarction, or urgent coronary revascularization in participants at risk for a first major cardiovascular event with elevated lipoprotein(a) (Lp\[a\]).
Who May Be Eligible (Plain English)
Who May Qualify:
- Age ≥50 years
- Lp(a)≥ 200 nmol/L during screening
- Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis
Who Should NOT Join This Trial:
- Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia)
- Prior or planned arterial revascularization
- History of major bleeding disorder
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Age ≥50 years
* Lp(a)≥ 200 nmol/L during screening
* Multiple atherosclerotic cardiovascular disease risk factors, and/or evidence of atherosclerosis
Exclusion Criteria:
* Prior acute atherothrombotic event (myocardial infarction, stroke, transient ischemic attack, acute limb ischemia)
* Prior or planned arterial revascularization
* History of major bleeding disorder
Treatments Being Tested
DRUG
Olpasiran
Olpasiran will be administered via SC injection.
DRUG
Placebo
Placebo will be administered via SC injection.
Locations (20)
Advanced Cardiovascular LLC
Alexander City, Alabama, United States
University of Alabama Birmingham Saint Vincents Birmingham
Birmingham, Alabama, United States
Birmingham Clinical Research
Birmingham, Alabama, United States
Alliance For Multispecialty Research - Daphne
Daphne, Alabama, United States
Eastern Shore Research Institute
Fairhope, Alabama, United States
Heart Center Research LLC
Huntsville, Alabama, United States
CB Flock Research Corporation
Mobile, Alabama, United States
Phoenix Clinical
Phoenix, Arizona, United States
Elite Clinical Studies LLC
Phoenix, Arizona, United States
Hero Clinical Research
Phoenix, Arizona, United States
HonorHealth Research Institute
Scottsdale, Arizona, United States
Eclipse Clinical Research
Tucson, Arizona, United States
Lynn Institute of the Ozarks
Little Rock, Arkansas, United States
National Heart Institute
Beverly Hills, California, United States
310 Clinical Research
Inglewood, California, United States
University of California San Diego
La Jolla, California, United States
InvivoCure
Los Angeles, California, United States
Valley Clinical Trials
Northridge, California, United States
Clinical Trials Research - Sacramento
Roseville, California, United States
Alliance Clinical Research
San Diego, California, United States