Evaluation of Efficacy and Safety of AR882 and XOI Co-administration in Uricase Treatment Failed Patients

Who May Qualify: - History of uncontrolled gout - Presence of ≥1 clinically visible tophus - Last uricase infusion occurred ≥3 months - Body weight no less than 50 kg - Serum creatinine must be \< 3.0 mg/dL and estimated CLcr ≥ 40 mL/min Who Should NOT Join This Trial: - Malignancy within 5 years, except for successfully treated basal or squamous cell carcinoma of the skin - Pregnant or breastfeeding - History of symptomatic kidney stones within the past 6 months - Received pegloticase, rasburicase or other experimental uricases within the last 3 months Always talk to your doctor about whether this trial is right for you.