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RECRUITINGOBSERVATIONAL

Late-Onset Seizures: Trial of Vascular Risk Investigation and Treatment

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

A growing body of evidence suggests patients with late-onset seizures are at an increased risk of stroke, but the potential for reducing cardiovascular morbidity through risk factor screening and management is unknown. The investigators aim to determine whether individuals with new-onset unprovoked seizures after middle age should undergo vascular risk assessment. In a cluster project the investigators assess the effect of vascular risk factor screening in an observational study as well as a cohort study. The project has two interlinked components: a prospective single group study, in which risk factor assessment is performed and subsequent management is followed for one year; and a register-based cohort study examining the long-term effects of the intervention on a system level.

Who May Be Eligible (Plain English)

Inclusion Criteria Clinical study: \- First assessment for unprovoked seizures or epilepsy with onset after age 50 -- - vascular risk factor evaluation per the new routine at participating care givers Register study: - age ≥50 with a first-ever outpatient appointment to one of the participating clinics and - a first-listed diagnostic code for seizures or epilepsy (ICD-10: R568, G40) Exclusion Criteria Clinical study: - Inability to consent. - Progressive brain disease (tumour or degenerative) Register study: - preexisting seizures/epilepsy, as demonstrated by a registered diagnostic code for seizures (ICD-10: R568, G40, G41) or a dispensed antiseizure medication (ATC-code: N03) more than 3 months before the initial consultation - a registered diagnostic code for stroke or TIA (ICD-10: I61, I63, I64, or G45 except G454) before the initial consultation, or - progressive brain disease, as indicated by diagnostic codes or drug prescriptions suggestive of brain tumors (ICD-10: C71, D33, D43, C793) or - neurocognitive disorders (ICD-10: F00-F03, F051, G30, G318, G912; ATC code: N06D). Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria Clinical study: \- First assessment for unprovoked seizures or epilepsy with onset after age 50 -- - vascular risk factor evaluation per the new routine at participating care givers Register study: * age ≥50 with a first-ever outpatient appointment to one of the participating clinics and * a first-listed diagnostic code for seizures or epilepsy (ICD-10: R568, G40) Exclusion Criteria Clinical study: * Inability to consent. * Progressive brain disease (tumour or degenerative) Register study: * preexisting seizures/epilepsy, as demonstrated by a registered diagnostic code for seizures (ICD-10: R568, G40, G41) or a dispensed antiseizure medication (ATC-code: N03) more than 3 months before the initial consultation * a registered diagnostic code for stroke or TIA (ICD-10: I61, I63, I64, or G45 except G454) before the initial consultation, or * progressive brain disease, as indicated by diagnostic codes or drug prescriptions suggestive of brain tumors (ICD-10: C71, D33, D43, C793) or * neurocognitive disorders (ICD-10: F00-F03, F051, G30, G318, G912; ATC code: N06D).

Treatments Being Tested

OTHER

Vascuar risk factor screening (blood pressure, medical history, BMI, laboratory tests)

The vascular risk assessment is outlined below, there may be slight variations according to local routines. Overall, the screening should include: Family history of vascular disease Tests/examinations (order or obtain from medical records \[past 3 months\]) Weight Height Waist circumference 12-lead ECG Resting and standing blood pressure Total cholesterol HDL cholesterol LDL cholesterol HbA1c High sensitivity CRP Serum creatinine Urine albumin-to-creatinine ratio Medical history Atherosclerotic cardiovascular disease Atrial fibrillation Congestive heart failure Diabetes mellitus Hypertension Kidney disease Life-style risk factors (smoking, exercis

Locations (3)

Södra Älvsborg Sjukhus
Borås, Sweden
Salgrenska University Hospital
Gothenburg, Sweden
Skånes universitetssjukhus
Malmo, Sweden