A Study of JNJ-95437446 in Participants With Advanced-Stage Solid Tumors

Who May Qualify: - Participants must have been previously diagnosed with diagnosed by tissue sample (biopsy-confirmed) unresectable, locally advanced, or metastatic non-small cell lung cancer, colorectal carcinoma, or head and neck squamous cell carcinoma - Participants with non-small cell lung cancer (NSCLC) adenocarcinoma and colorectal cancer (CRC) must have local molecular testing to determine epidermal growth factor receptor (EGFR) mutational status for NSCLC and Kirsten rat sarcoma/neuroblastoma ras viral oncogene/v-raf murine sarcoma oncogene B1 (KRAS/NRAS/BRAF) mutation status for CRC - Have measurable or evaluable disease: - Part 1: Either measurable or evaluable disease; Part 2: At least 1 measurable lesion per response evaluation criteria in solid tumors (RECIST) version (v) 1.1 - Have an eastern cooperative oncology group (ECOG) performance status of 0 to 1 at screening - Participants must have appropriate hematologic, renal, and hepatic function within the required limits Who Should NOT Join This Trial: - Any prior medical history of ILD/pneumonitis, including pneumonitis from anti-PD-1/ PD-L1 antibody or radiation that required systemic steroids - Toxicity from prior anticancer therapy that has not resolved to Grade \<=1 - Evidence of clinically significant active viral, bacterial, or fungal infection within 7 days before the first dose of study treatment requiring systemic or non-topical treatment - History of clinically significant cardiovascular disease within 6 months prior to signing willing to sign a consent form - Participants with prior or concurrent second malignancy cannot be enrolled if prior/concurrent malignancy's natural history of treatment is likely to interfere with any safety or efficacy study endpoints Always talk to your doctor about whether this trial is right for you.