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RECRUITINGINTERVENTIONAL

Efficacy of a Myocardial Panel in the Management and Treatment of Pediatric Myocarditis

Efficacy of a Myocardial Panel (Virological, Bacterial and Autoimmune) in the Management and Treatment of Pediatric Myocarditis Complicated With Arrhythmias or Ventricular Dysfunction

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The goal of this observational study is to determine the efficacy a of combined management and treatment driven by the systematic determination of viral genome, bacterial serology, and markers of inflammation in pediatric patients (\< 18 years old) diagnosed with myocarditis complicated by arrhythmias (supraventricular and ventricular tachycardias and heart block) or ventricular dysfunction (left ventricular ejection fraction \< 50% or right ventricular fractional area change \< 35%). The main question it aims to answer is: Does this panel help resolve arrhythmias or myocardial dysfunction due to myocarditis during hospitalisation and follow-up? Researchers will compare patients managed and treated in 2024 without applying the myocarditis panel with those enrolled in 2025 who received the panel. Arrhythmias and myocardial dysfunction will be managed in accordance with recent guidelines. Antiviral, antibiotic or immunosuppressive therapies will be implemented in addition to standard therapy when required by the panel.

Who May Be Eligible (Plain English)

Who May Qualify: - All the consecutive pediatric patients (\< 18 years old) presenting with myocarditis complicated by arrhythmias or myocardial dysfunction Who Should NOT Join This Trial: - Refused consent to be included in the study given by parents or legal tutors - Uncomplicated myocarditis presenting without arrhythmias or myocardial dysfunction Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * All the consecutive pediatric patients (\< 18 years old) presenting with myocarditis complicated by arrhythmias or myocardial dysfunction Exclusion Criteria: * Refused consent to be included in the study given by parents or legal tutors * Uncomplicated myocarditis presenting without arrhythmias or myocardial dysfunction

Treatments Being Tested

DIAGNOSTIC_TEST

Determination of viral genome, bacterial serology, and markers of inflammation in pediatrics diagnosed with myocarditis

N=15 patients from 2025, in which management and treatment of arrhythmias and or myocardial dysfunction were driven by the panel

Locations (1)

Francesco Bianco
Ancona, The Marches, Italy