A Study to Assess Bioequivalence of Two Subcutaneous (SC) Formulations of Ocrelizumab in Participants With Multiple Sclerosis (MS)

Who May Qualify: - Diagnosis of RMS or PPMS according to the revised McDonald 2017 criteria (Thompson et al. 2018) or the most current McDonald criteria at the time of study start - Expanded Disability Status Scale (EDSS) score, 0-6.5, inclusive, at screening Who Should NOT Join This Trial: - Participants who have previously received anti-cluster of differentiation (CD) 20s (including ocrelizumab) less than 2 years before screening - Participants who have previously received anti-CD20s (including ocrelizumab) more than 2 years before screening if one of the following conditions is met: B-cell count is below lower limit of normal (LLN), or the discontinuation of the treatment was due to safety reasons - History of confirmed or suspected progressive multifocal leukoencephalopathy (PML) - History of cancer, including hematologic malignancy and solid tumors, within 10 years of screening - Immunocompromised state - Sensitivity or intolerance to any ingredient (including excipients) of ocrelizumab - History of severe allergic or anaphylactic reactions to humanized or murine monoclonal antibodies - Any concomitant disease that may require chronic treatment with systemic corticosteroids or immunosuppressants during the course of the study - Significant, uncontrolled disease, such as cardiovascular, pulmonary, renal, hepatic, endocrine or gastrointestinal, or any other significant disease that may preclude participation in the study - Lack of peripheral venous access - Previous treatment with cladribine, atacicept, and alemtuzumab - Any previous treatment with bone marrow transplantation and hematopoietic stem cell transplantation - Any previous history of transplantation or anti-rejection therapy - Positive screening tests for active, latent, or inadequately treated hepatitis B virus (HBV) Always talk to your doctor about whether this trial is right for you.