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RECRUITINGINTERVENTIONAL

Non-invasive Brain Stimulation and Exercise Intervention for Patients With Motor Neuron Disease

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

Motor neuron disease (MND) is a progressive neurological disorder involving degeneration of motor neurons, leading to muscle weakness, speech and swallowing difficulties, and respiratory failure. This study aims to develop a novel treatment approach combining personalized repetitive transcranial magnetic stimulation (rTMS) with mixed reality (MR) exercise-based games (exergames) to slow disease progression and improve quality of life. In this randomised controlled trial study will compare three groups: (1) rTMS with MR exercise (personalized intervention), (2) rTMS with MR exercise (standard intervention), and (3) sham rTMS with MR exercise. Outcomes will be assessed at baseline, 3 months, and 6 months post intervention. The long-term goal is to implement this approach in clinical settings to enhance care for people with MND.

Who May Be Eligible (Plain English)

Who May Qualify: - Participants aged between 18 and 80 years - Diagnosed with any type of motor neuron disease (MND) - Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3 Who Should NOT Join This Trial: - History of other neurological disorders, such as stroke - Use of ventilatory support - Severe dementia Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Participants aged between 18 and 80 years * Diagnosed with any type of motor neuron disease (MND) * Have mild to moderate severity, as assessed by the Sinaki-Mulder scale, with a severity level between 1 and 3 Exclusion Criteria: * History of other neurological disorders, such as stroke * Use of ventilatory support * Severe dementia

Treatments Being Tested

DEVICE

Personalized rTMS

Personalized repetitive transcranial magnetic stimulation (TMS) together with mixed-reality (MR) exercise

DEVICE

Standard rTMS

Standard repetitive transcranial magnetic stimulation (TMS) together with mixed-reality (MR) exercise

DEVICE

Sham rTMS

Sham rTMS together with mixed-reality (MR) exercise

Locations (1)

King Chulalongkorn Memorial hospital, The Thai Red Cross Society
Bangkok, Pathumwan, Thailand