RECRUITINGINTERVENTIONAL
Assessment of Circuit Rebreathing During CPAP Therapy
Assessment of Circuit Rebreathing During Continuous Positive Airway Pressure (CPAP) Therapy
About This Trial
The goal of this research is to better understand how different CPAP mask designs affect airflow and rebreathing of exhaled carbon dioxide (CO₂) during sleep in individuals with obstructive sleep apnea (OSA).
Who May Be Eligible (Plain English)
Who May Qualify:
- Moderate to severe OSA (AHI\>20)
- Self-reported CPAP users or have previously used CPAP
- Self-reported holding pressure of maximum 13 cmH2O (if known)
- Age: 21-70
- BMI: 18-40 kg/m2
Who Should NOT Join This Trial:
- Self-reported severe mouth-breathing
- Requirement for nocturnal supplemental oxygen or other ventilatory support
- Severe cardiovascular or pulmonary disease
- Any unstable or acute medical condition
- Any additional sleep disorder, including insomnia, except for OSA.
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* Moderate to severe OSA (AHI\>20)
* Self-reported CPAP users or have previously used CPAP
* Self-reported holding pressure of maximum 13 cmH2O (if known)
* Age: 21-70
* BMI: 18-40 kg/m2
Exclusion Criteria:
* Self-reported severe mouth-breathing
* Requirement for nocturnal supplemental oxygen or other ventilatory support
* Severe cardiovascular or pulmonary disease
* Any unstable or acute medical condition
* Any additional sleep disorder, including insomnia, except for OSA.
Treatments Being Tested
DEVICE
Continuous positive airway pressure (CPAP)
Subjects will be administered either 0, 5 or 10 cmH2O
OTHER
Mask exhaust port flow
Subjects will be administered varying levels of exhaust flow: 35, 23, 18, 13 and 8 L/s
Locations (1)
Brigham and Women's Hospital
Boston, Massachusetts, United States