Obstructive Sleep Apnea Treatment From Acute to Chronic Phase of Stroke

Who May Qualify: - Supratentorial non-lacunar ischemic stroke, including anterior, middle, and posterior cerebral artery territories - Aged 18 to 80 years - Symptom onset or symptom recognition to admission \< 12 hours - NIHSS score ≥ 4 and ≤ 20 at enrollment - Signed willing to sign a consent form form obtained from the participant or their legal representative Who Should NOT Join This Trial: - Prior stroke - Previous diagnosis of OSA with current CPAP use or previously failed CPAP - Pre-stroke disability (mRS \> 1) - Coma or stupor - Orotracheal intubation - Clinical instability or severe pre-existing illness (e.g., heart failure, oxygen-dependent COPD, renal or hepatic failure) - Psychomotor agitation - High likelihood of neurosurgical intervention within the first 48 hours - Oxygen therapy \>2 L/min - Known severe neurological disease (e.g., dementia, Parkinson's disease, multiple sclerosis, or other neurodegenerative conditions) - Chronic alcohol or drug use with high risk of withdrawal during hospitalization - Pregnant or suspected pregnant women - Inability to complete follow-up for any reason - Any contraindication to CPAP use Always talk to your doctor about whether this trial is right for you.