Early Screening and Treatment of Heart Complication in Sickle Cell Disease

Who May Qualify: - At least 18 years of age - Diagnosis of sickle cell disease (any genotype) - Serum ferritin levels ≥ 400 ng/mL (up to 80 patients), or less than 400 ng/mL in those who have cardiac symptoms including shortness of breath and lower extremity edema (up to 20 patients) - Willingness to undergo regular imaging (echocardiograms, ECG, cardiac MRI) - You should be able to carry out daily activities with 0 level of ability (ECOG 0)-1 - Able to read, understand and provide written willing to sign a consent form - Deemed appropriate for participation by the treating physician Who Should NOT Join This Trial: - Unable to schedule and required follow-up visits - Medical comorbidities including: - Known heart failure - Unstable angina - Uncontrolled dysrhythmias - Acute pulmonary embolism - Active infection or severe comorbid conditions that in the view of the investigator would limit participation - History of hypersensitivity or contraindication to chelation therapy - Severe renal or hepatic impairment - Pregnancy of breastfeeding Always talk to your doctor about whether this trial is right for you.