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RECRUITINGINTERVENTIONAL

Minimal Vitrectomy Surgery for Epiretinal Membrane

Minimal Vitrectomy Surgery (MVS) Versus Conventional Vitrectomy for the Treatment of Idiopathic Epiretinal Membrane: A Multicenter Randomized Controlled Trial

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

This multicenter randomized controlled trial evaluates Minimal Vitrectomy Surgery (MVS) versus conventional vitrectomy for idiopathic epiretinal membrane (ERM). The primary endpoints include visual acuity improvement and cataract progression after 12 months. MVS aims to minimize vitreous removal while ensuring complete membrane removal through adaptive limited vitrectomy.

Who May Be Eligible (Plain English)

Who May Qualify: 1. Age ≥ 18 years. 2. Diagnosis of idiopathic epiretinal membrane (ERM) confirmed by clinical examination and OCT imaging. 3. Clear ocular media allowing adequate fundus imaging. 4. Phakic eye. 5. Ability and willingness to provide written willing to sign a consent form. Who Should NOT Join This Trial: 1. Prior cataract surgery or advanced cataract requiring combined surgery. Co-existing retinal diseases (e.g., diabetic retinopathy, retinal detachment, retinal vein occlusion). 2. Systemic conditions preventing safe surgery or follow-up. 3. History of prior ocular or periocular corticosteroid use, including intraocular injection, periocular injection, or long-term topical corticosteroid eye drops. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: 1. Age ≥ 18 years. 2. Diagnosis of idiopathic epiretinal membrane (ERM) confirmed by clinical examination and OCT imaging. 3. Clear ocular media allowing adequate fundus imaging. 4. Phakic eye. 5. Ability and willingness to provide written informed consent. Exclusion Criteria: 1. Prior cataract surgery or advanced cataract requiring combined surgery. Co-existing retinal diseases (e.g., diabetic retinopathy, retinal detachment, retinal vein occlusion). 2. Systemic conditions preventing safe surgery or follow-up. 3. History of prior ocular or periocular corticosteroid use, including intraocular injection, periocular injection, or long-term topical corticosteroid eye drops.

Treatments Being Tested

PROCEDURE

Minimal Vitrectomy Surgery

The epiretinal membrane is peeled directly through the intact vitreous. Limited localized vitrectomy is selectively performed if pre-existing floaters or membrane fragments remain after peeling.

PROCEDURE

Conventional Vitrectomy

Standard pars plana vitrectomy is performed with posterior vitreous detachment induction and core vitreous removal prior to epiretinal membrane peeling.

Locations (1)

Peking Union Medical College Hospital
Beijing, Beijing Municipality, China