RECRUITINGOBSERVATIONAL

Multiparametric MRI for Characterization of Hepatocellular Carcinoma

Multiparametric MRI for Optimized Imaging-based Characterization and Therapy Management of Hepatocellular Carcinoma

About This Trial

This prospective observational study investigates using multiparametric magnetic resonance imaging (MRI) to improve the characterization and management of therapy for hepatocellular carcinoma (HCC). The goal is to evaluate whether advanced MRI parameters can support noninvasive diagnostic assessments and personalized treatment plans for patients with HCC. The study is being conducted at a single university center in Germany and includes adult patients with confirmed or suspected HCC. Participants will undergo standardized multiparametric MRI examinations, and the imaging data will be correlated with clinical, pathological, and therapeutic outcomes. No study-specific interventions or medications will be administered.

Who May Be Eligible (Plain English)

Who May Qualify: - Age ≥18 years - Confirmed or suspected diagnosis of HCC - Scheduled to receive TACE or SIRT as part of standard clinical care - Eligibility for liver MRI - Willing and able to provide written willing to sign a consent form Who Should NOT Join This Trial: - Contraindications to MRI (e.g., pacemakers, ferromagnetic implants, severe claustrophobia) - Known allergy or intolerance to gadolinium-based contrast agents - Renal insufficiency with estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m² - Pregnancy or breastfeeding - Inability to provide willing to sign a consent form Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: * Age ≥18 years * Confirmed or suspected diagnosis of HCC * Scheduled to receive TACE or SIRT as part of standard clinical care * Eligibility for liver MRI * Willing and able to provide written informed consent Exclusion Criteria: * Contraindications to MRI (e.g., pacemakers, ferromagnetic implants, severe claustrophobia) * Known allergy or intolerance to gadolinium-based contrast agents * Renal insufficiency with estimated glomerular filtration rate (eGFR) \<30 mL/min/1.73m² * Pregnancy or breastfeeding * Inability to provide informed consent

Treatments Being Tested

DIAGNOSTIC_TEST

Multiparametric MRI

Diagnostic multiparametric liver MRI, performed at three time points: before (≤14 days), 24 hours after, and 4-6 weeks after TACE or 3 months after SIRT.

Locations (1)

Clinic of Radiology, University of Münster

Münster, Germany