Cerebral Large Vessel Occlusion Stroke Multiomics Biosample Cohort

Who May Qualify: 1. Age over 18 years. 2. Patients with intracranial and extracranial large vessel occlusion ischemic stroke confirmed by cerebrovascular angiography. 3. Availability of complete clinical and follow-up information required for the study. 4. Availability of blood and/or thrombus biological samples. 5. Voluntary written willing to sign a consent form signed by the patient or their family (1) For retrospectively enrolled patients, a "broad willing to sign a consent form" was signed at the time of sample collection. Upon enrollment into the cohort, a follow-up phone call was made to confirm the willing to sign a consent form. (2) For prospectively enrolled patients, willing to sign a consent form for this study was signed at the time of enrollment by the patient or their family. Who Should NOT Join This Trial: 1. Patients for whom biological samples cannot be obtained; 2. Patients or their family members who refuse to sign the willing to sign a consent form form. Always talk to your doctor about whether this trial is right for you.