RECRUITINGINTERVENTIONAL

Ultrasound Perfusion Estimation for Assessment of Peripheral Arterial Disease

Ultrasound Perfusion Estimation for Assessment of PAD

About This Trial

The purpose of this study is to develop a new noninvasive tool for early diagnosis of Peripheral Arterial Disease (PAD) and use the proposed method for monitoring the disease progression and the response to interventional treatment in PAD patients.

Who May Be Eligible (Plain English)

Who May Qualify: Patient volunteers: - Male and Female, ages 18 years old and up - Symptom of claudication and suspected for PAD - Scheduled for vascular testing. Healthy volunteers: - Male and female, ages 18-75 years old and up - Normal BMI - No history of smoking, cardiovascular disease, or diabetes. Who Should NOT Join This Trial: Patient volunteers: - Patients with gangrene - Patients having surgery or stent - Patients with ulcer on their leg - Any health condition that does not allow proper use of ultrasound scanning - People considered in "vulnerable" populations. Healthy volunteers: - Include volunteers with BMI not more than 30 - No history of smoking - No history of (diabetes, hypertension, cardiovascular diseases) - People considered in "vulnerable" populations. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language

Inclusion Criteria: Patient volunteers: * Male and Female, ages 18 years old and up * Symptom of claudication and suspected for PAD * Scheduled for vascular testing. Healthy volunteers: * Male and female, ages 18-75 years old and up * Normal BMI * No history of smoking, cardiovascular disease, or diabetes. Exclusion Criteria: Patient volunteers: * Patients with gangrene * Patients having surgery or stent * Patients with ulcer on their leg * Any health condition that does not allow proper use of ultrasound scanning * People considered in "vulnerable" populations. Healthy volunteers: * Include volunteers with BMI not more than 30 * No history of smoking * No history of (diabetes, hypertension, cardiovascular diseases) * People considered in "vulnerable" populations.

Treatments Being Tested

DIAGNOSTIC_TEST

Ultrasound Imaging

Non-invasive ultrasound will be performed using Angio Flow Reactivity Analysis (AFRA) The ultrasound probe will be attached to the subject's calf muscle and a pressure cuff will be secured around thigh. Ultrasound data will be collected for 1 minute. The cuff will then be induced to a tolerable pressure of no more than 160 mm Hg, and ultrasound data will be collected for 3 minutes while cuff is inflated. The cuff pressure will be released, and ultrasound data will be collected for 2 minutes after the release. Subject will be asked to perform 1 minute plantar flexion exercise, and ultrasound data will be collected for two minutes after the completion of exercise

Locations (1)

Mayo Clinic in Rochester

Rochester, Minnesota, United States