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RECRUITINGINTERVENTIONAL

The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabolic Syndrome

The Impact of 12 Weeks Intervention With Plant-based Oat Drink Rich in Short-chain Fatty Acids on Postprandial Lipidemia in Individuals at Risk for Metabolic Syndrome

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

During this study, the effect of short-chain fatty acids on blood lipaedemia, glycemia, anthropometrics, blood pressure and energy expenditure will be investigated.

Who May Be Eligible (Plain English)

Who May Qualify: - male and female participants - central obesity ( BMI ≥ 25 kg/m² or waist circumference ≥ 80 cm for women/ ≥ 94 cm for men) - One additional risk factor for metabolic syndrome: 1. Insulin resistance (HOMA-IR ≥ 1.7 or fasting glucose ≥ 100 mg/dl) 2. Triglyceride concentration ≥ 150 mg/dl 3. HDL-cholesterol \< 40 mg/dl for women/ \< 50 mg/dl for men 4. Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg - knowledge of English Who Should NOT Join This Trial: - gastrointestinal disorders such as IBD, IBS, celiac disease, chronic constipation, chronic diarrhoea - history of abdominal surgery, except for appendectomy - Use of antihypertensive, cholesterol lowering, glucose-regulating drugs and corticosteroids - Use of antibiotics 3 months prior to the start or during the study - Use of probiotics and prebiotics 2 weeks prior to the start of the study/ during the study - Being on weight loss, gluten-free, lactose-free or vegan diet - Pregnancy, lactation or wish to become pregnant - Previous or current substance/ alcohol dependence or abuse - Hyper- or hypothyroidism - Allergy or intolerance to oat milk Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * male and female participants * central obesity ( BMI ≥ 25 kg/m² or waist circumference ≥ 80 cm for women/ ≥ 94 cm for men) * One additional risk factor for metabolic syndrome: 1. Insulin resistance (HOMA-IR ≥ 1.7 or fasting glucose ≥ 100 mg/dl) 2. Triglyceride concentration ≥ 150 mg/dl 3. HDL-cholesterol \< 40 mg/dl for women/ \< 50 mg/dl for men 4. Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg * knowledge of English Exclusion Criteria: * gastrointestinal disorders such as IBD, IBS, celiac disease, chronic constipation, chronic diarrhoea * history of abdominal surgery, except for appendectomy * Use of antihypertensive, cholesterol lowering, glucose-regulating drugs and corticosteroids * Use of antibiotics 3 months prior to the start or during the study * Use of probiotics and prebiotics 2 weeks prior to the start of the study/ during the study * Being on weight loss, gluten-free, lactose-free or vegan diet * Pregnancy, lactation or wish to become pregnant * Previous or current substance/ alcohol dependence or abuse * Hyper- or hypothyroidism * Allergy or intolerance to oat milk

Treatments Being Tested

DIETARY_SUPPLEMENT

with short-chain fatty acids enriched drink

Oat-based drink enriched with 15 g/L short-chain fatty acids

DIETARY_SUPPLEMENT

unenriched oat drink

Oat-based drink

Locations (1)

KU Leuven/ UZ Leuven
Leuven, Vlaams-Brabant, Belgium