RECRUITINGINTERVENTIONAL
The Impact of Daily Intake of Short-chain Fatty Acids on Cardiometabolic Risk Factors in Individuals at Risk for Metabolic Syndrome
The Impact of 12 Weeks Intervention With Plant-based Oat Drink Rich in Short-chain Fatty Acids on Postprandial Lipidemia in Individuals at Risk for Metabolic Syndrome
About This Trial
During this study, the effect of short-chain fatty acids on blood lipaedemia, glycemia, anthropometrics, blood pressure and energy expenditure will be investigated.
Who May Be Eligible (Plain English)
Who May Qualify:
- male and female participants
- central obesity ( BMI ≥ 25 kg/m² or waist circumference ≥ 80 cm for women/ ≥ 94 cm for men)
- One additional risk factor for metabolic syndrome:
1. Insulin resistance (HOMA-IR ≥ 1.7 or fasting glucose ≥ 100 mg/dl)
2. Triglyceride concentration ≥ 150 mg/dl
3. HDL-cholesterol \< 40 mg/dl for women/ \< 50 mg/dl for men
4. Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg
- knowledge of English
Who Should NOT Join This Trial:
- gastrointestinal disorders such as IBD, IBS, celiac disease, chronic constipation, chronic diarrhoea
- history of abdominal surgery, except for appendectomy
- Use of antihypertensive, cholesterol lowering, glucose-regulating drugs and corticosteroids
- Use of antibiotics 3 months prior to the start or during the study
- Use of probiotics and prebiotics 2 weeks prior to the start of the study/ during the study
- Being on weight loss, gluten-free, lactose-free or vegan diet
- Pregnancy, lactation or wish to become pregnant
- Previous or current substance/ alcohol dependence or abuse
- Hyper- or hypothyroidism
- Allergy or intolerance to oat milk
Always talk to your doctor about whether this trial is right for you.
Original Eligibility Criteria
View original clinical language
Inclusion Criteria:
* male and female participants
* central obesity ( BMI ≥ 25 kg/m² or waist circumference ≥ 80 cm for women/ ≥ 94 cm for men)
* One additional risk factor for metabolic syndrome:
1. Insulin resistance (HOMA-IR ≥ 1.7 or fasting glucose ≥ 100 mg/dl)
2. Triglyceride concentration ≥ 150 mg/dl
3. HDL-cholesterol \< 40 mg/dl for women/ \< 50 mg/dl for men
4. Systolic blood pressure ≥ 130 mmHg or diastolic blood pressure ≥ 85 mmHg
* knowledge of English
Exclusion Criteria:
* gastrointestinal disorders such as IBD, IBS, celiac disease, chronic constipation, chronic diarrhoea
* history of abdominal surgery, except for appendectomy
* Use of antihypertensive, cholesterol lowering, glucose-regulating drugs and corticosteroids
* Use of antibiotics 3 months prior to the start or during the study
* Use of probiotics and prebiotics 2 weeks prior to the start of the study/ during the study
* Being on weight loss, gluten-free, lactose-free or vegan diet
* Pregnancy, lactation or wish to become pregnant
* Previous or current substance/ alcohol dependence or abuse
* Hyper- or hypothyroidism
* Allergy or intolerance to oat milk
Treatments Being Tested
DIETARY_SUPPLEMENT
with short-chain fatty acids enriched drink
Oat-based drink enriched with 15 g/L short-chain fatty acids
DIETARY_SUPPLEMENT
unenriched oat drink
Oat-based drink
Locations (1)
KU Leuven/ UZ Leuven
Leuven, Vlaams-Brabant, Belgium