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RECRUITINGPhase 2INTERVENTIONAL

Metformin in Safety and Efficacy in Gouty Patients

the Impact of Metformin Use on Clinical Outcomes in Gouty Patients

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The most frequent crystal arthropathy is gout, which is also the most prevalent cause of inflammatory arthritis. Gouty Patients frequently have excruciating pain and swelling in their joints. Gout is linked to decreased health-related quality of life and functional disability. Gout and its associated diseases have been shown to have a significant impact on patients mortality and morbidities. Metformin, a biguanide, is used to manage diabetes by reducing insulin resistance and preventing comorbidities such as cerebrovascular and coronary artery disease, as well as providing renal protection to diabetic nephropathy patients

Who May Be Eligible (Plain English)

Who May Qualify: - Gouty patients clinically diagnosed as gouty arthritis based on the American College of Rheumatology/European League Against Rheumatism criteria of gout. Who Should NOT Join This Trial: - Systemic disorders such as cardiovascular, neurological, coronary artery disease. - Hypertension, hyperlipidemia, diabetes mellitus, active infections. - Other inflammatory or autoimmune conditions (where your immune system attacks your own body)s. - Patients on biologics, - Cases with hypersensitivity to metformin and those with impaired liver and kidney functions. Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Gouty patients clinically diagnosed as gouty arthritis based on the American College of Rheumatology/European League Against Rheumatism criteria of gout. Exclusion Criteria: * Systemic disorders such as cardiovascular, neurological, coronary artery disease. * Hypertension, hyperlipidemia, diabetes mellitus, active infections. * Other inflammatory or autoimmune diseases. * Patients on biologics, * Cases with hypersensitivity to metformin and those with impaired liver and kidney functions.

Treatments Being Tested

OTHER

placebo

Placebo will have the same look of metformin

DRUG

Metformin

Metformin, a biguanide, is used to manage diabetes by reducing insulin resistance and preventing comorbidities such as cerebrovascular and coronary artery disease, as well as providing renal protection to diabetic nephropathy patients

Locations (1)

Tanta Unuversity
Tanta, Egypt