Sickle Cell, Pain and Mediterranean Diet

Who May Qualify: - Sickle Cell Disease Diagnosis - Chronic non-vaso-occlusive pain experienced on average ≥ 3 days per week for \> 6 months (based on a response of "Most days," "Every day," or "Some days" and not "Never" to the question "In the past 6 months, how often have you had pain?") - Ability to speak, read, write, and understand English - A Mediterranean Eating Pattern for Americans (MEPA-III) score \<13, indicating that they do not follow a Mediterranean diet. Who Should NOT Join This Trial: - Having taken systemic antimicrobials (to treat an infection in the previous 4 weeks) - History of colon cancer or inflammatory bowel disease (given potential untoward effects on the gut microbiome) - History of Clostridium difficile infection in the preceding 12 weeks; (4) unable to agree to maintain physical activity at the current level for the duration of the study - Currently following a Mediterranean diet, vegan diet, or dietary restrictions (e.g., religious, food intolerance/allergy) that preclude adoption of a Mediterranean diet - Lack of access to a space to safely store and reheat food items - Living in a facility that provides meals. - Pregnancy or breastfeeding - More than 7 in-patient hospital stays in the last year - Currently receiving dialysis treatment Always talk to your doctor about whether this trial is right for you.