Feasibility of a Minimally Invasive Diagnostic Algorithm in Suspected Crohn's Disease

Who May Qualify: - Clinical suspicion of CD\* - Age 18-40 years - Signed willing to sign a consent form \*A clinical suspicion of CD is based on the following definition: - Diarrhea and/or abdominal pain for more than 1 month (or repeated episodes of diarrhea and/or abdominal pain) and either - fecal calprotectin ≥ 200 mg/kg or - fecal calprotectin ≥ 50 mg/kg plus one or more of the following findings: - C-reactive protein (CRP) \> 5 mg/L - Thrombocytosis (\> 400 x 109/L) - Anemia (hemoglobin \< 7.0 mmol/L for women and \< 8.0 mmol/L for men or a decrease \> 0.5 mmol/L compared to the usual level) - Prolonged fever (\> 37.5 ◦C for more than 2 weeks) - Weight loss (≥ 3 kg or ≥ 5% compared to the normal body weight) - Perianal abscess / fistula - Family history of inflammatory bowel disease. Who Should NOT Join This Trial: - Previous intestinal resection - Positive serologic markers for celiac disease - Positive stool polymerase chain reaction for pathogenic bacteria - Positive stool polymerase chain reaction for intestinal parasites - Suspected or established acute bowel obstruction (ileus) - Intake of NSAIDs or acetylsalicylic acid ≤ 4 weeks before inclusion, except low-dose, prophylactic acetylsalicylic acid (≤ 150 mg per day) - Intake of opioid or opioid-like medications ≤ 1 week before inclusion - Pregnancy or lactation - Inability to comply with protocol requirements, e.g. for reasons including alcohol or recreational drug abuse - Known gastrointestinal disorder other than functional gastrointestinal disorders - Renal failure defined by a plasma-creatinine above the normal reference range Always talk to your doctor about whether this trial is right for you.