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RECRUITINGOBSERVATIONAL

Early Detection of CTEPH in Patients After APE

Early Detection of Chronic Thromboembolic Pulmonary Hypertension in Patients After Acute Pulmonary Embolism

Important: This information is not medical advice. Talk to your doctor about whether a clinical trial is right for you.

About This Trial

The project is a national, prospective, multicenter, observational pilot project of screening CTEPH in pacients after APE in the Czech Republic. The main goal of the project is to methodically prepare, implement and evaluate a pilot project that will verify the suitability of the proposed procedure of early detection of Chronic tromboembolic pulmonary hypertesion in such a way as to ensure the maximum positive impact on the health of the population and high cost-effectiveness of the whole process.

Who May Be Eligible (Plain English)

Who May Qualify: - Age over 18 years - Signed consent to participate in the project and GDPR - Patients with an episode of acute pulmonary embolism in the last 3-12 months, with ongoing anticoagulation therapy: 1. Patients with new-onset and ongoing or progressive dyspnea (min. NYHA II) after a pulmonary embolism episode or worsening of dyspnea after a pulmonary embolism episode compared to the status before the episode (at least 1 HYHA grade) or 2. Asymptomatic patients after a pulmonary embolism episode and at least one of the following risk factors: - ECHO evidence of severe PH at diagnosis of PE (PASP \>60 mmHg) - Antiphospholipid syndrome with triple positivity (presence of lupus anticoagulans + anti-beta-2-glycoprotein I (B2GPI) antibodies + anticardiolipin) - Infected permanent venous inlets and cardiac pacing/defibrillation intravascular systems - Presence of ventriculoatrial shunt for treatment of hydrocephalus - Nonspecific intestinal inflammation (ulcerative colitis, Crohn's disease) - History of splenectomy - Myeloproliferative disorders - Chronic osteomyelitis Who Should NOT Join This Trial: - Not agreeing to participate in the project - Contraindications to treatment Always talk to your doctor about whether this trial is right for you.

Original Eligibility Criteria

View original clinical language
Inclusion Criteria: * Age over 18 years * Signed consent to participate in the project and GDPR * Patients with an episode of acute pulmonary embolism in the last 3-12 months, with ongoing anticoagulation therapy: 1. Patients with new-onset and ongoing or progressive dyspnea (min. NYHA II) after a pulmonary embolism episode or worsening of dyspnea after a pulmonary embolism episode compared to the status before the episode (at least 1 HYHA grade) or 2. Asymptomatic patients after a pulmonary embolism episode and at least one of the following risk factors: * ECHO evidence of severe PH at diagnosis of PE (PASP \>60 mmHg) * Antiphospholipid syndrome with triple positivity (presence of lupus anticoagulans + anti-beta-2-glycoprotein I (B2GPI) antibodies + anticardiolipin) * Infected permanent venous inlets and cardiac pacing/defibrillation intravascular systems * Presence of ventriculoatrial shunt for treatment of hydrocephalus * Nonspecific intestinal inflammation (ulcerative colitis, Crohn's disease) * History of splenectomy * Myeloproliferative disorders * Chronic osteomyelitis Exclusion Criteria: * Not agreeing to participate in the project * Contraindications to treatment

Treatments Being Tested

OTHER

Standardized CTEPH Screening Protocol

Implementation of a standardized screening algorithm for early detection of CTEPH in patients after Acute Pulmonary Embolism (APE) and establishment of optimized referral of patients to specialized centers.

Locations (10)

Brno University Hospital
Brno, Czechia
Havlíčkův Brod Hospital
Havlíčkův Brod, Czechia
University Hospital Hradec Králové
Hradec Králové, Czechia
Jihlava Hospital
Jihlava, Czechia
Náchod Hospital
Náchod, Czechia
University Hospital Olomouc
Olomouc, Czechia
University Hospital Ostrava
Ostrava, Czechia
Pardubice Hospital
Pardubice, Czechia
Rychnov nad Kněžnou Hospital
Rychnov nad Kněžnou, Czechia
Tábor Hospital
Tábor, Czechia